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INDICATIVE · SAMPLE DATA
PSNL$8.5059

Personalis Inc

Biotechnology & Medical ResearchVerified

Personalis maintains a strong liquidity position with $119.3 million in cash and equivalents, which is 1.7 times its total liabilities of $72.98 million, as reflected in a current ratio of 6.76. The company's price-to-book ratio of 3.41 suggests that the market is valuing its equity at a premium relative to its book value, while the price-to-tangible-book ratio is identical, indicating no significant intangible assets. The company's debt-to-equity ratio of 0.02 is well below the industry median, suggesting a conservative capital structure with minimal leverage. Profitability metrics for Personalis are negative, with a return on equity (ROE) of -31.12% and a return on assets (ROA) of -24.32%, both significantly below the industry median for biotechnology firms. The company reported a net loss of $81.27 million on revenue of $69.65 million, with an operating loss of $88.06 million, indicating that it is not yet generating positive operating cash flow. Geographically, Personalis does not disclose segment-specific revenue data, but its operations are primarily concentrated in the United States, as is typical for biotechnology firms in the diagnostics space. The company's revenue is derived from a single business model focused on genomic data services, which may expose it to concentration risk if demand for its services declines or if it fails to expand into new therapeutic areas. Looking ahead, Personalis is expected to continue operating at a loss, with no significant revenue growth anticipated in the near term. The company's free cash flow has been negative for the period, at -$75.73 million, and its capital expenditures of -$4.5 million suggest ongoing investment in infrastructure. Analysts have assigned a mean price target of $10.86, with a median of $11.00, indicating a potential upside of 28% from the current market price of $8.50. Risk factors for Personalis include its reliance on a single business model and the absence of positive operating cash flow, which could limit its ability to fund operations without external financing. The company has not issued any dilutive shares in the period, and no immediate dilution risks were identified in filings. However, the company's negative net income and operating cash flow could necessitate future equity or debt financing, which may lead to share dilution. Recent events include the continued focus on genomic data for precision medicine, with Personalis expanding its partnerships in oncology and other therapeutic areas. The company has not filed any material adverse events or regulatory actions in the period, and its risk assessment remains low for liquidity and dilution.

30-day price · PSNL+4.32 (+64.9%)
Low$4.96High$11.05Close$10.98As of28 May, 00:00 UTC
Profile
CompanyPersonalis Inc
TickerPSNL.O
SectorHealthcare
BusinessPharmaceuticals & Medical Research
Industry groupPharmaceuticals & Medical Research
IndustryBiotechnology & Medical Research
AI analysis

Business. Personalis Inc is a biotechnology company that provides genomic data and insights to support the development of precision medicine therapies, primarily through its proprietary genome sequencing and analysis platform.

Classification. Personalis is classified under the Healthcare economic sector, within the Pharmaceuticals & Medical Research business sector, and the Biotechnology & Medical Research industry, with a classification confidence of 0.92.

Personalis maintains a strong liquidity position with $119.3 million in cash and equivalents, which is 1.7 times its total liabilities of $72.98 million, as reflected in a current ratio of 6.76. The company's price-to-book ratio of 3.41 suggests that the market is valuing its equity at a premium relative to its book value, while the price-to-tangible-book ratio is identical, indicating no significant intangible assets. The company's debt-to-equity ratio of 0.02 is well below the industry median, suggesting a conservative capital structure with minimal leverage. Profitability metrics for Personalis are negative, with a return on equity (ROE) of -31.12% and a return on assets (ROA) of -24.32%, both significantly below the industry median for biotechnology firms. The company reported a net loss of $81.27 million on revenue of $69.65 million, with an operating loss of $88.06 million, indicating that it is not yet generating positive operating cash flow. Geographically, Personalis does not disclose segment-specific revenue data, but its operations are primarily concentrated in the United States, as is typical for biotechnology firms in the diagnostics space. The company's revenue is derived from a single business model focused on genomic data services, which may expose it to concentration risk if demand for its services declines or if it fails to expand into new therapeutic areas. Looking ahead, Personalis is expected to continue operating at a loss, with no significant revenue growth anticipated in the near term. The company's free cash flow has been negative for the period, at -$75.73 million, and its capital expenditures of -$4.5 million suggest ongoing investment in infrastructure. Analysts have assigned a mean price target of $10.86, with a median of $11.00, indicating a potential upside of 28% from the current market price of $8.50. Risk factors for Personalis include its reliance on a single business model and the absence of positive operating cash flow, which could limit its ability to fund operations without external financing. The company has not issued any dilutive shares in the period, and no immediate dilution risks were identified in filings. However, the company's negative net income and operating cash flow could necessitate future equity or debt financing, which may lead to share dilution. Recent events include the continued focus on genomic data for precision medicine, with Personalis expanding its partnerships in oncology and other therapeutic areas. The company has not filed any material adverse events or regulatory actions in the period, and its risk assessment remains low for liquidity and dilution.
Key takeaways
  • Personalis has a strong liquidity position with $119.3 million in cash and equivalents, but it is not generating positive operating cash flow.
  • The company's ROE and ROA are significantly negative, indicating poor profitability relative to industry peers.
  • Personalis operates in a concentrated business model with no disclosed geographic or segment diversification.
  • Analysts project a potential upside of 28% from the current market price, but the company is expected to remain unprofitable in the near term.
  • The company has no immediate dilution risks, but its negative cash flow could necessitate future financing.
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Financial snapshot
PeriodHA-latest
CurrencyUSD
Revenue$69.6M
Gross profit$15.8M
Operating income-$88.1M
Net income-$81.3M
R&D
SG&A
D&A
SBC
Operating cash flow-$74.9M
CapEx-$4.5M
Free cash flow-$75.7M
Total assets$334.2M
Total liabilities$73.0M
Total equity$261.2M
Cash & equivalents$119.3M
Long-term debt$5.3M
Valuation
Market price$8.50
Market cap$889.8M
Enterprise value$775.7M
P/E
Reported non-GAAP P/E
EV/Revenue11.1
EV/Op income
EV/OCF
P/B3.4
P/Tangible book3.4
Tangible book$261.2M
Net cash$114.1M
Current ratio6.8
Debt/Equity0.0
ROA-24.3%
ROE-31.1%
Cash conversion92.0%
CapEx/Revenue-6.5%
SBC/Revenue
Asset intensity
Dilution ratio0.0%
Risk assessment
Dilution riskLow
Liquidity riskLow
  • No immediate filing-based liquidity or dilution flags were detected.
Industry benchmarks
Activity: Healthcare Diagnostics · cohort 170 companies
MetricPSNLActivity
Op margin-126.4%-227.5% medp25 -1250.6% · p75 -3.5%above median
Net margin-116.7%-194.5% medp25 -1233.8% · p75 0.8%above median
Gross margin22.7%53.0% medp25 25.9% · p75 75.7%bottom quartile
CapEx / revenue-6.5%-8.2% medp25 -35.2% · p75 -2.5%above median
Debt / equity2.0%1.2% medp25 0.0% · p75 17.4%above median
Observations
IR observations
Mean price target10.86 USD
Median price target11.00 USD
High price target13.00 USD
Low price target9.00 USD
Mean recommendation1.86 (1=strong buy, 5=strong sell)
Strong-buy count2.00
Buy count4.00
Hold count1.00
Sell count0.00
Strong-sell count0.00
Mean EPS estimate-1.02 USD
Last actual EPS-0.91 USD
Source data
Underlying data the analysis-pipeline pulls and audits. Fetch timestamps + content hashes show when each source was last refreshed.
Company fundamentalsperiod financials
no public URL
2026-05-23 01:53 UTC#ef327c6a
Source: analysis-pipeline (hybrid)Generated: 2026-05-29 02:09 UTCJob: 70939950