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INDICATIVE · SAMPLE DATA
PRME$2.9859

Prime Medicine Inc

Biotechnology & Medical ResearchVerified

Prime Medicine operates with a capital structure that is entirely equity-funded, as it has no long-term debt and a debt-to-equity ratio of 0.0. The company maintains a strong liquidity position, with $63.03 million in cash and equivalents and a current ratio of 4.84, indicating a robust ability to meet short-term obligations. However, its liquidity is constrained by negative operating and free cash flows of -$162.56 million and -$198.35 million, respectively, which reflect ongoing operational losses. The company's profitability metrics are weak, with a net loss of $201.14 million and an operating loss of $208.35 million. Its return on equity (ROE) is -1.66, and return on assets (ROA) is -0.59, both significantly below the industry median for biotechnology firms. The price-to-book ratio of 4.46 suggests that the market is valuing the company at a premium to its tangible book value, likely due to expectations of future growth rather than current earnings. Prime Medicine's revenue is concentrated in a single business segment, as disclosed in its financial reporting, with no geographic diversification provided in the available data. This lack of segment or geographic diversification increases exposure to market-specific risks, particularly in the biotechnology sector where regulatory and clinical trial outcomes can significantly impact revenue streams. The company's growth trajectory is currently negative, with a revenue of $4.63 million in the latest period. Analysts have not provided forward-looking revenue guidance, but the company is expected to remain in a development phase with no near-term revenue growth. The absence of positive operating cash flow and the continued burn rate suggest that the company will need to raise additional capital to fund operations, which could lead to further dilution of existing shareholders. Risk factors for Prime Medicine include the high costs and uncertainties associated with drug development, including clinical trial failures, regulatory delays, and competition from more established biotechnology firms. The company has not issued any recent dilutive events, and its dilution risk is currently assessed as low. However, the need for continued capital raises could increase dilution risk in the future. Recent events include the continued development of its mRNA platform and the initiation of clinical trials for its lead programs. The company has not filed any recent material adverse events or significant regulatory actions, and its risk assessment remains stable. Analysts have assigned a mean price target of $7.04, with a median of $6.00, indicating a generally positive outlook despite the company's current financial position.

30-day price · PRME-0.69 (-18.9%)
Low$2.68High$4.03Close$2.97As of22 May, 00:00 UTC
Profile
CompanyPrime Medicine Inc
TickerPRME.O
SectorHealthcare
BusinessPharmaceuticals & Medical Research
Industry groupPharmaceuticals & Medical Research
IndustryBiotechnology & Medical Research
AI analysis

Business. Prime Medicine Inc is a biotechnology company focused on developing messenger RNA (mRNA) therapeutics for the treatment of genetic diseases, leveraging its proprietary messenger RNA platform to design and deliver novel therapies.

Classification. Prime Medicine is classified under the Healthcare economic sector, within the Pharmaceuticals & Medical Research business sector, and the Biotechnology & Medical Research industry, with a classification confidence of 0.92.

Prime Medicine operates with a capital structure that is entirely equity-funded, as it has no long-term debt and a debt-to-equity ratio of 0.0. The company maintains a strong liquidity position, with $63.03 million in cash and equivalents and a current ratio of 4.84, indicating a robust ability to meet short-term obligations. However, its liquidity is constrained by negative operating and free cash flows of -$162.56 million and -$198.35 million, respectively, which reflect ongoing operational losses. The company's profitability metrics are weak, with a net loss of $201.14 million and an operating loss of $208.35 million. Its return on equity (ROE) is -1.66, and return on assets (ROA) is -0.59, both significantly below the industry median for biotechnology firms. The price-to-book ratio of 4.46 suggests that the market is valuing the company at a premium to its tangible book value, likely due to expectations of future growth rather than current earnings. Prime Medicine's revenue is concentrated in a single business segment, as disclosed in its financial reporting, with no geographic diversification provided in the available data. This lack of segment or geographic diversification increases exposure to market-specific risks, particularly in the biotechnology sector where regulatory and clinical trial outcomes can significantly impact revenue streams. The company's growth trajectory is currently negative, with a revenue of $4.63 million in the latest period. Analysts have not provided forward-looking revenue guidance, but the company is expected to remain in a development phase with no near-term revenue growth. The absence of positive operating cash flow and the continued burn rate suggest that the company will need to raise additional capital to fund operations, which could lead to further dilution of existing shareholders. Risk factors for Prime Medicine include the high costs and uncertainties associated with drug development, including clinical trial failures, regulatory delays, and competition from more established biotechnology firms. The company has not issued any recent dilutive events, and its dilution risk is currently assessed as low. However, the need for continued capital raises could increase dilution risk in the future. Recent events include the continued development of its mRNA platform and the initiation of clinical trials for its lead programs. The company has not filed any recent material adverse events or significant regulatory actions, and its risk assessment remains stable. Analysts have assigned a mean price target of $7.04, with a median of $6.00, indicating a generally positive outlook despite the company's current financial position.
Key takeaways
  • Prime Medicine is a biotechnology company with no long-term debt and a strong liquidity position, but it is experiencing significant operating losses.
  • The company's financial performance is weak, with a negative ROE and ROA, and its valuation is based on future growth expectations rather than current earnings.
  • Revenue is concentrated in a single segment, and there is no geographic diversification disclosed, increasing exposure to market-specific risks.
  • Analysts have a generally positive outlook, with a mean price target of $7.04, but the company will need to raise additional capital to fund operations.
  • The company's risk profile is moderate, with low dilution risk currently, but the need for continued capital raises could increase dilution risk in the future.
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Financial snapshot
PeriodHA-latest
CurrencyUSD
Revenue$4.6M
Gross profit
Operating income-$208.3M
Net income-$201.1M
R&D
SG&A
D&A
SBC
Operating cash flow-$162.6M
CapEx-$4.5M
Free cash flow-$198.4M
Total assets$342.7M
Total liabilities$221.9M
Total equity$120.9M
Cash & equivalents$63.0M
Long-term debt$0.00
Valuation
Market price$2.98
Market cap$539.1M
Enterprise value$476.1M
P/E
Reported non-GAAP P/E
EV/Revenue102.8
EV/Op income
EV/OCF
P/B4.5
P/Tangible book4.5
Tangible book$120.9M
Net cash$63.0M
Current ratio4.8
Debt/Equity0.0
ROA-58.7%
ROE-1.7%
Cash conversion81.0%
CapEx/Revenue-97.8%
SBC/Revenue
Asset intensity
Dilution ratio0.0%
Risk assessment
Dilution riskLow
Liquidity riskLow
  • No immediate filing-based liquidity or dilution flags were detected.
Industry benchmarks
Activity: Pharmaceuticals & Medical Research · cohort 693 companies
MetricPRMEActivity
Op margin-4498.1%2.4% medp25 -91.8% · p75 12.5%bottom quartile
Net margin-4342.4%1.2% medp25 -98.4% · p75 10.4%bottom quartile
Gross margin45.6% medp25 29.8% · p75 66.7%
CapEx / revenue-97.8%-5.2% medp25 -15.8% · p75 -1.7%bottom quartile
Debt / equity0.0%9.3% medp25 0.1% · p75 43.8%bottom quartile
Observations
IR observations
Mean price target7.04 USD
Median price target6.00 USD
High price target11.00 USD
Low price target4.25 USD
Mean recommendation2.00 (1=strong buy, 5=strong sell)
Strong-buy count4.00
Buy count5.00
Hold count4.00
Sell count0.00
Strong-sell count0.00
Mean EPS estimate-0.98 USD
Last actual EPS-1.35 USD
Source data
Underlying data the analysis-pipeline pulls and audits. Fetch timestamps + content hashes show when each source was last refreshed.
Company fundamentalsperiod financials
no public URL
2026-05-23 01:36 UTC#c8dd2777
Source: analysis-pipeline (hybrid)Generated: 2026-05-29 01:37 UTCJob: 38537768