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INDICATIVE · SAMPLE DATA
PTGX$102.1858

Protagonist Therapeutics Inc

Biotechnology & Medical ResearchVerified

Capital Structure and Liquidity Protagonist Therapeutics Inc maintains a strong liquidity position, with $128.39 million in cash and equivalents and a current ratio of 12.71, indicating a robust ability to meet short-term obligations. The company has no long-term debt and a debt-to-equity ratio of 0.0, suggesting a conservative capital structure. The price-to-book ratio of 10.69 and price-to-tangible-book ratio of 10.69 reflect a premium valuation relative to its book value. ### Profitability and Returns The company reported a net loss of $130.15 million and an operating loss of $158.13 million, with a return on equity of -21.17% and return on assets of -19.48%. These figures indicate a lack of profitability and underperformance relative to industry norms. The enterprise value to EBITDA ratio of -40.74 and enterprise value to revenue ratio of 140.0 highlight the speculative nature of the investment, as the company is not currently generating positive earnings. ### Segments and Geographic Exposure Protagonist Therapeutics Inc operates as a single business segment focused on the development of peptide-based therapeutics. The company's revenue is not disclosed by geographic region, but its operations are primarily based in the United States. The lack of geographic diversification may expose the company to regional regulatory and market risks. ### Growth Trajectory The company is in a pre-revenue phase, with no historical revenue growth to analyze. Analysts have set a mean price target of $114.17, with a median of $116.50 and a high of $125.00, suggesting a positive outlook on the stock despite the current financial losses. The company's future growth will depend on the success of its clinical trials and the commercialization of its pipeline candidates. ### Risk Factors The company faces significant financial risk due to its negative net income and operating income. However, the risk of dilution is currently low, as there are no immediate filing-based liquidity or dilution flags. The company's reliance on external financing for continued operations introduces potential dilution risk in the future. ### Recent Events Recent filings and transcripts have not indicated any major events that would significantly impact the company's financial position or strategic direction. The company continues to focus on its clinical development pipeline, with no major changes in its business strategy reported.

30-day price · PTGX-0.71 (-0.7%)
Low$95.40High$107.00Close$102.18As of17 May, 00:00 UTC
Profile
CompanyProtagonist Therapeutics Inc
TickerPTGX.O
SectorHealthcare
BusinessPharmaceuticals & Medical Research
Industry groupPharmaceuticals & Medical Research
IndustryBiotechnology & Medical Research
AI analysis

Business. Protagonist Therapeutics Inc is a clinical-stage biopharmaceutical company focused on the discovery and development of novel peptide-based therapeutics for the treatment of immune and inflammatory diseases, with a pipeline including candidates for inflammatory bowel disease and other gastrointestinal disorders.

Classification. Protagonist Therapeutics Inc is classified under the Healthcare economic sector, within the Pharmaceuticals & Medical Research business sector, and the Biotechnology & Medical Research industry, with a classification confidence of 0.92.

### Capital Structure and Liquidity Protagonist Therapeutics Inc maintains a strong liquidity position, with $128.39 million in cash and equivalents and a current ratio of 12.71, indicating a robust ability to meet short-term obligations. The company has no long-term debt and a debt-to-equity ratio of 0.0, suggesting a conservative capital structure. The price-to-book ratio of 10.69 and price-to-tangible-book ratio of 10.69 reflect a premium valuation relative to its book value. ### Profitability and Returns The company reported a net loss of $130.15 million and an operating loss of $158.13 million, with a return on equity of -21.17% and return on assets of -19.48%. These figures indicate a lack of profitability and underperformance relative to industry norms. The enterprise value to EBITDA ratio of -40.74 and enterprise value to revenue ratio of 140.0 highlight the speculative nature of the investment, as the company is not currently generating positive earnings. ### Segments and Geographic Exposure Protagonist Therapeutics Inc operates as a single business segment focused on the development of peptide-based therapeutics. The company's revenue is not disclosed by geographic region, but its operations are primarily based in the United States. The lack of geographic diversification may expose the company to regional regulatory and market risks. ### Growth Trajectory The company is in a pre-revenue phase, with no historical revenue growth to analyze. Analysts have set a mean price target of $114.17, with a median of $116.50 and a high of $125.00, suggesting a positive outlook on the stock despite the current financial losses. The company's future growth will depend on the success of its clinical trials and the commercialization of its pipeline candidates. ### Risk Factors The company faces significant financial risk due to its negative net income and operating income. However, the risk of dilution is currently low, as there are no immediate filing-based liquidity or dilution flags. The company's reliance on external financing for continued operations introduces potential dilution risk in the future. ### Recent Events Recent filings and transcripts have not indicated any major events that would significantly impact the company's financial position or strategic direction. The company continues to focus on its clinical development pipeline, with no major changes in its business strategy reported.
Key takeaways
  • Protagonist Therapeutics Inc has a strong liquidity position with no long-term debt and a high current ratio.
  • The company is not currently profitable, with significant net and operating losses.
  • The company's valuation is speculative, with high enterprise value to revenue and negative enterprise value to EBITDA ratios.
  • Analysts have a generally positive outlook on the stock, with a mean price target above the current market price.
  • The company's future growth is contingent on the success of its clinical trials and the commercialization of its pipeline.
  • --
  • ## RATIONALES
  • ```json
Financial snapshot
PeriodHA-latest
CurrencyUSD
Revenue$46.0M
Gross profit
Operating income-$158.1M
Net income-$130.1M
R&D
SG&A
D&A
SBC
Operating cash flow$57.7M
CapEx-$1.6M
Free cash flow-$130.5M
Total assets$668.2M
Total liabilities$53.5M
Total equity$614.7M
Cash & equivalents$128.4M
Long-term debt$0.00
Valuation
Market price$102.18
Market cap$6.57B
Enterprise value$6.44B
P/E
Reported non-GAAP P/E
EV/Revenue140.0
EV/Op income
EV/OCF111.7
P/B10.7
P/Tangible book10.7
Tangible book$614.7M
Net cash$128.4M
Current ratio12.7
Debt/Equity0.0
ROA-19.5%
ROE-21.2%
Cash conversion-44.0%
CapEx/Revenue-3.5%
SBC/Revenue
Asset intensity
Dilution ratio0.0%
Risk assessment
Dilution riskLow
Liquidity riskLow
  • No immediate filing-based liquidity or dilution flags were detected.
Industry benchmarks
Activity: Healthcare Diagnostics · cohort 170 companies
MetricPTGXActivity
Op margin-343.6%-227.5% medp25 -1250.6% · p75 -3.5%below median
Net margin-282.8%-194.5% medp25 -1233.8% · p75 0.8%below median
Gross margin53.0% medp25 25.9% · p75 75.7%
CapEx / revenue-3.5%-8.2% medp25 -35.2% · p75 -2.5%above median
Debt / equity0.0%1.2% medp25 0.0% · p75 17.4%bottom quartile
Observations
IR observations
Mean price target114.17 USD
Median price target116.50 USD
High price target125.00 USD
Low price target97.00 USD
Mean recommendation1.77 (1=strong buy, 5=strong sell)
Strong-buy count4.00
Buy count8.00
Hold count1.00
Sell count0.00
Strong-sell count0.00
Mean EPS estimate3.23 USD
Last actual EPS-2.05 USD
Source data
Underlying data the analysis-pipeline pulls and audits. Fetch timestamps + content hashes show when each source was last refreshed.
Company fundamentalsperiod financials
no public URL
2026-05-16 02:25 UTC#2c4f68d9
Market quoteclose USD 102.07 · shares 0.06B diluted
no public URL
2026-05-16 02:27 UTC#66c5ebd7
Source: analysis-pipeline (hybrid)Generated: 2026-05-29 02:17 UTCJob: 69da1eed