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INDICATIVE · SAMPLE DATA
UPB$8.4659

Upstream Bio Inc

Biotechnology & Medical ResearchVerified

Upstream Bio Inc has a strong liquidity position, with a current ratio of 26.15, indicating that the company holds significantly more current assets than current liabilities. The company's cash and equivalents amount to $101.58 million, which is a substantial portion of its total assets of $353.77 million. The absence of long-term debt further supports the company's liquidity profile, with a debt-to-equity ratio of 0.0. The company's profitability metrics are currently negative, with a return on equity (ROE) of -42.22% and a return on assets (ROA) of -40.55%. These figures indicate that the company is not generating returns for its shareholders or effectively utilizing its assets. The net income for the period is -$143.44 million, and the operating income is -$160.36 million, reflecting significant operational losses. Upstream Bio Inc's revenue is concentrated in a single business segment, as disclosed in its financial statements. The company does not provide detailed geographic revenue breakdowns, but its operations are primarily based in the United States. The lack of geographic diversification could pose a risk if the company's primary market experiences economic downturns or regulatory changes. The company's growth trajectory is currently constrained by its negative operating and net income. The outlook for the current fiscal year does not indicate a significant improvement in revenue or profitability. The company's capital expenditures are relatively low at -$165,000, suggesting minimal investment in new projects or expansion. The risk assessment for Upstream Bio Inc indicates low liquidity and dilution risks. The company has no immediate filing-based liquidity or dilution flags, and its strong cash position supports this assessment. However, the company's negative net income and operating cash flow of -$133.28 million suggest that it may need to raise additional capital in the future, which could lead to dilution for existing shareholders. Recent events and filings do not indicate any significant changes in the company's financial or operational status. The company's financial statements and disclosures have not revealed any material risks or liabilities that would impact its operations or financial health. The company's management has not announced any major strategic initiatives or restructuring plans.

30-day price · UPB-1.86 (-18.2%)
Low$7.99High$10.64Close$8.37As of22 May, 00:00 UTC
Profile
CompanyUpstream Bio Inc
TickerUPB.O
SectorHealthcare
BusinessPharmaceuticals & Medical Research
Industry groupPharmaceuticals & Medical Research
IndustryBiotechnology & Medical Research
AI analysis

Business. Upstream Bio Inc is a biotechnology company focused on healthcare diagnostics, developing and commercializing innovative diagnostic solutions to support patient care and treatment decisions.

Classification. Upstream Bio Inc is classified under the Healthcare economic sector, within the Pharmaceuticals & Medical Research business sector, and the Biotechnology & Medical Research industry, with a confidence level of 0.92.

Upstream Bio Inc has a strong liquidity position, with a current ratio of 26.15, indicating that the company holds significantly more current assets than current liabilities. The company's cash and equivalents amount to $101.58 million, which is a substantial portion of its total assets of $353.77 million. The absence of long-term debt further supports the company's liquidity profile, with a debt-to-equity ratio of 0.0. The company's profitability metrics are currently negative, with a return on equity (ROE) of -42.22% and a return on assets (ROA) of -40.55%. These figures indicate that the company is not generating returns for its shareholders or effectively utilizing its assets. The net income for the period is -$143.44 million, and the operating income is -$160.36 million, reflecting significant operational losses. Upstream Bio Inc's revenue is concentrated in a single business segment, as disclosed in its financial statements. The company does not provide detailed geographic revenue breakdowns, but its operations are primarily based in the United States. The lack of geographic diversification could pose a risk if the company's primary market experiences economic downturns or regulatory changes. The company's growth trajectory is currently constrained by its negative operating and net income. The outlook for the current fiscal year does not indicate a significant improvement in revenue or profitability. The company's capital expenditures are relatively low at -$165,000, suggesting minimal investment in new projects or expansion. The risk assessment for Upstream Bio Inc indicates low liquidity and dilution risks. The company has no immediate filing-based liquidity or dilution flags, and its strong cash position supports this assessment. However, the company's negative net income and operating cash flow of -$133.28 million suggest that it may need to raise additional capital in the future, which could lead to dilution for existing shareholders. Recent events and filings do not indicate any significant changes in the company's financial or operational status. The company's financial statements and disclosures have not revealed any material risks or liabilities that would impact its operations or financial health. The company's management has not announced any major strategic initiatives or restructuring plans.
Key takeaways
  • Upstream Bio Inc has a strong liquidity position with a current ratio of 26.15 and no long-term debt.
  • The company is currently unprofitable, with a return on equity of -42.22% and a return on assets of -40.55%.
  • Revenue is concentrated in a single business segment, with no detailed geographic breakdown provided.
  • The company's growth trajectory is constrained by negative operating and net income.
  • Low liquidity and dilution risks are indicated, but the company may need to raise additional capital in the future.
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Financial snapshot
PeriodHA-latest
CurrencyUSD
Revenue$2.9M
Gross profit
Operating income-$160.4M
Net income-$143.4M
R&D
SG&A
D&A
SBC
Operating cash flow-$133.3M
CapEx-$165.0k
Free cash flow-$143.4M
Total assets$353.8M
Total liabilities$14.0M
Total equity$339.8M
Cash & equivalents$101.6M
Long-term debt$0.00
Valuation
Market price$8.46
Market cap$460.4M
Enterprise value$358.8M
P/E
Reported non-GAAP P/E
EV/Revenue125.7
EV/Op income
EV/OCF
P/B1.4
P/Tangible book1.4
Tangible book$339.8M
Net cash$101.6M
Current ratio26.1
Debt/Equity0.0
ROA-40.6%
ROE-42.2%
Cash conversion93.0%
CapEx/Revenue-5.8%
SBC/Revenue
Asset intensity
Dilution ratio0.0%
Risk assessment
Dilution riskLow
Liquidity riskLow
  • No immediate filing-based liquidity or dilution flags were detected.
Industry benchmarks
Activity: Healthcare Diagnostics · cohort 170 companies
MetricUPBActivity
Op margin-5618.8%-227.5% medp25 -1250.6% · p75 -3.5%bottom quartile
Net margin-5026.0%-194.5% medp25 -1233.8% · p75 0.8%bottom quartile
Gross margin53.0% medp25 25.9% · p75 75.7%
CapEx / revenue-5.8%-8.2% medp25 -35.2% · p75 -2.5%above median
Debt / equity0.0%1.2% medp25 0.0% · p75 17.4%bottom quartile
Observations
IR observations
Mean price target43.50 USD
Median price target42.50 USD
High price target75.00 USD
Low price target15.00 USD
Mean recommendation2.00 (1=strong buy, 5=strong sell)
Strong-buy count1.00
Buy count6.00
Hold count1.00
Sell count0.00
Strong-sell count0.00
Mean EPS estimate-2.97 USD
Last actual EPS-2.66 USD
Source data
Underlying data the analysis-pipeline pulls and audits. Fetch timestamps + content hashes show when each source was last refreshed.
Company fundamentalsperiod financials
no public URL
2026-05-25 02:25 UTC#92fd9319
Source: analysis-pipeline (hybrid)Generated: 2026-05-29 21:10 UTCJob: c8fe4236