Agios Pharmaceuticals, Inc.
AGIOS Pharmaceuticals, Inc. is a biopharmaceutical company focused on developing therapies for serious diseases, currently generating limited revenue while incurring significant operating losses to fund its research and development pipeline.
Business. AGIOS Pharmaceuticals, Inc. (AGIO) is a pharmaceutical company operating within the Healthcare sector, specifically focused on the development and sale of pharmaceutical products. The company is headquartered in the United States and is primarily listed on the Nasdaq stock exchange. As no specific operating segments or geographic breakdowns are provided, the firm is described at the industry level as a participant in the broader pharmaceuticals market.
Analyst recommendations
10 analysts · consensus BuyAt a glance
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- Company
- EarningsQ3 2026 earnings (expected)2026-10-28 · estimated
- Macro
- Rate decisionBank of England rate decision (press conf.)2026-08-06 · GB
- Rate decisionReserve Bank of Australia rate decision (press conf.)2026-08-12 · AU
- Rate decisionNorges Bank rate decision (press conf.)2026-08-20 · NO
- Rate decisionSveriges Riksbank rate decision (press conf.)2026-09-03 · SE
- Rate decisionBank of Canada rate decision (press conf.)2026-09-09 · CA
- Rate decisionEuropean Central Bank rate decision (press conf.)2026-09-10 · EU
- Macro & political
- ElectionSE Swedish Election2026-09-14 · SE
- ElectionUS U.S. Midterms2026-11-03 · US
- ElectionFR French Legislative2027-06-01 · FR
- Congressional trades
- CongressJosh Gottheimer — Agios Pharmaceuticals, Inc.2024-01-24 · Democrat · NJ · Purchase · $1,001 - $15,000
Pre-earnings brief
Signals & dispatch
Composite-score breakdown
Synthesis
AGIOS Pharmaceuticals, Inc. (AGIO) is a pharmaceutical company operating within the Healthcare sector, specifically focused on the development and sale of pharmaceutical products. The company is headquartered in the United States and is primarily listed on the Nasdaq stock exchange. As no specific operating segments or geographic breakdowns are provided, the firm is described at the industry level as a participant in the broader pharmaceuticals market.
AGIOS Pharmaceuticals maintains a robust balance sheet characterized by zero debt and substantial liquidity. As of Q2 2026, the company holds $99.6 million in cash and equivalents, alongside significant marketable securities, resulting in a current ratio of 10.22. The debt-to-equity ratio stands at 0.0, indicating no leverage risk. The market capitalization is approximately $1.94 billion, with a price-to-book ratio of 1.89. The company’s total assets amount to $1.11 billion, while total liabilities are minimal at $82.4 million. This strong liquidity position supports ongoing operations without immediate refinancing needs.
The company is not yet profitable, reporting a net loss of $199.8 million and an operating loss of $220.6 million for the period. Return on equity is negative at -40.23%, and return on assets is -37.24%, reflecting the pre-commercial stage of its business model. Revenue for the quarter was $65.5 million, resulting in an EV/Revenue multiple of 34.0. The negative EV/EBITDA of -3.89 underscores the current lack of earnings. These metrics are typical for early-stage biopharma firms investing heavily in R&D before achieving commercial scale.
- Strong liquidity position with $99.6 million in cash and a current ratio of 10.22, mitigating short-term financial risk.
- Significant operating losses of $220.6 million and negative returns on equity and assets, typical for pre-commercial biopharma.
- Medium dilution risk flagged due to potential future capital raises, despite current zero debt.
- Analyst consensus suggests upside potential with a mean price target of $45.14, reflecting confidence in the pipeline.
- Recent 8-K filing indicates material corporate developments, warranting close monitoring of disclosures.
Bull / Bear case
Generated · model-assistedAnalysts project 37.8% upside to a mean price target of $45.14, reflecting strong buy consensus among ten covering analysts.
The company maintains a pristine balance sheet with zero long-term debt and a debt-to-equity ratio of just 0.0873.
Revenue demonstrated a 16.6% compound annual growth rate from FY2023 to FY2025, indicating expanding top-line momentum.
Agios exhibits best-in-class capital efficiency with a Capex-to-Revenue ratio of 0.0799, outperforming the pharmaceutical cohort median.
Liquidity risk is assessed as low, supported by a robust current ratio of 11.46 as of late 2025.
Operating income deteriorated to a loss of $472.1 million in FY2025, widening the operating deficit compared to prior periods.
The company faces medium dilution risk, which could erode shareholder value as it continues to fund significant operating losses.
Free cash flow turned negative at -$377.3 million in FY2025, highlighting persistent cash burn despite revenue growth.
Return on invested capital stands at -46.02%, signaling severe inefficiency in generating returns from deployed capital.
In focus — financials by report
Revenue $65.5M; Operating income -$220.6M.
- ▍Revenue $65.5M
- ▍Operating income -$220.6M
- ▍Net margin -305.1%
Revenue $20.7M; Operating income -$110.0M.
- ▍Revenue $20.7M
- ▍Operating income -$110.0M
- ▍Net margin -477.7%
Revenue $54.0M; Operating income -$472.1M.
- ▍Revenue $54.0M
- ▍Operating income -$472.1M
- ▍Net margin -764.0%
Revenue $36.5M; Operating income -$425.7M.
- ▍Revenue $36.5M
- ▍Operating income -$425.7M
- ▍Net margin 1845.9%
Revenue $36.5M; Operating income -$425.7M.
- ▍Revenue $36.5M
- ▍Operating income -$425.7M
- ▍Net margin 1845.9%
Revenue $26.8M; Operating income -$391.5M.
- ▍Revenue $26.8M
- ▍Operating income -$391.5M
- ▍Net margin -1312.6%
Revenue $26.8M; Operating income -$391.5M.
- ▍Revenue $26.8M
- ▍Operating income -$391.5M
- ▍Net margin -1312.6%
Valuation FY
Revenue by segment
Business relationships
Supply chain
Peer comparison
Market position
Stress test
Predictor forecast
| Metric | Our forecast | Guidance | Consensus |
|---|---|---|---|
| EPS | —no estimate | —no estimate | -6,26 |
| Revenue | —no estimate | —no estimate | 123,1M USD |
| Operating income | —no estimate | —no estimate | -416,4M USD |
Options
Short squeeze
Earnings-call key lines
Consensus distribution
sell-side coverageEstimate revisions
consensus EPS · 26-week trendSell-side observations
Themes
ESG
Risk factors
- Source documents mention dilution or offering risk.
Benchmarks vs cohort
Corporate actions / M&A
FX exposure
Comparable transactions
Derivatives & instruments
Derivative transactions
- Director · Restricted stock units → Common stockDisposed 1 447exercise · 2026-07-08
- Chief Medical Officer · Restricted stock units → Common stockDisposed 8 375exercise · 2026-07-01
- Director · Stock options (right to buy) → Common stockAcquired 14 950 @ $34,16grant · 2026-06-18
- Chief Strategy and Operations · Performance share units → Common stockDisposed 3 000exercise · 2026-06-18
- Chief Strategy and Operations · Restricted stock units → Common stockAcquired 3 000grant · 2026-06-18
- Director, Chief Executive Officer · Performance share units → Common stockDisposed 39 000exercise · 2026-06-18
- Director, Chief Executive Officer · Restricted stock units → Common stockAcquired 39 000grant · 2026-06-18
- Chief Legal Officer · Performance share units → Common stockDisposed 3 000exercise · 2026-06-18
- Director · Restricted stock units → Common stockDisposed 2 816exercise · 2026-06-18
- Director · Stock options (right to buy) → Common stockAcquired 14 950 @ $34,16grant · 2026-06-18
- Director · Restricted stock units → Common stockAcquired 2 927grant · 2026-06-18
- Chief Commercial Officer · Restricted stock units → Common stockAcquired 3 000grant · 2026-06-18
- Chief Commercial Officer · Performance share units → Common stockDisposed 3 000exercise · 2026-06-18
- Chief Financial Officer · Restricted stock units → Common stockAcquired 3 000grant · 2026-06-18
- Chief Financial Officer · Performance share units → Common stockDisposed 3 000exercise · 2026-06-18
- Chief Medical Officer · Restricted stock units → Common stockAcquired 3 000grant · 2026-06-18
- Chief Medical Officer · Performance share units → Common stockDisposed 3 000exercise · 2026-06-18
- Chief Legal Officer · Restricted stock units → Common stockAcquired 3 000grant · 2026-06-18
- Director · Restricted stock units → Common stockAcquired 2 927grant · 2026-06-18
- Director · Restricted stock units → Common stockAcquired 2 927grant · 2026-06-18
- Director · Restricted stock units → Common stockDisposed 2 816exercise · 2026-06-18
- Director · Stock options (right to buy) → Common stockAcquired 14 950 @ $34,16grant · 2026-06-18
- Director · Restricted stock units → Common stockAcquired 2 927grant · 2026-06-18
- Director · Restricted stock units → Common stockDisposed 2 816exercise · 2026-06-18
- Director · Stock options (right to buy) → Common stockAcquired 14 950 @ $34,16grant · 2026-06-18
Actions
Ask Handelsavisen
- Market data
- Regulatory filings
- Issuer disclosures
- Public news
- Earnings transcripts
- Consensus estimates
- ESG data
- Reference data
- Cash Conversion Ratiooperating_cash_flow / net_income
- Market Priceinput from market-data provider (delayed close or quote-shim mid)
- Ev To Revenueenterprise_value / revenue
- Net Cashcash_and_equivalents + short_term_investments - short_term_debt - long_term_debt
- Return On Equitynet_income / total_equity
- Market Capmarket_price * shares_outstanding_diluted
- AGIOS PHARMACEUTICALS, INC. company facts · 2026-07-31
- AGIOS PHARMACEUTICALS, INC. 10-Q 2026-07-30 · 2026-07-31
- AGIOS PHARMACEUTICALS, INC. 10-Q 2026-04-29 · 2026-07-31
- AGIOS PHARMACEUTICALS, INC. 10-K 2026-02-12 · 2026-07-31
- AGIOS PHARMACEUTICALS, INC. 10-Q 2025-10-30 · 2026-07-31
- 8-K (sec_8k_material) on AGIO · 2026-07-31
- Agios Pharmaceuticals Inc Market data — analyst estimates · 2026-07-31
- Agios Pharmaceuticals Inc Market data — ESG · 2026-07-31
- AGIOS PHARMACEUTICALS, INC. HA canonical relationships · 2026-07-31
Ownership & reference
Top holders
- Investment Managers · as of 2026-03-310,03 %$0M
- Investment Managers · as of 2026-03-310,01 %$39M
- Investment Managers · as of 2024-06-300,00 %$210M
- Investment Managers · as of 2026-03-310,00 %$8M
- Investment Managers · as of 2026-03-310,00 %$22M
- Investment Managers · as of 2026-03-310,00 %$114M
- Investment Managers · as of 2026-03-310,00 %$27M
- Investment Managers · as of 2026-03-310,00 %$50M
- Institutional Investor · as of 2022-09-300,00 %$0M
- Investment Managers · as of 2026-03-310,00 %$16M
- Investment Managers · as of 2026-03-310,00 %$17M
- Investment Managers · as of 2025-12-310,00 %$152M
- Investment Managers · as of 2026-03-310,00 %$4M
- Investment Managers · as of 2026-03-310,00 %$33M
- Investment Managers · as of 2024-12-310,00 %$5M
- Investment Managers · as of 2026-03-310,00 %$0M
- Institutional Investor · as of 2026-03-310,00 %$6M
- Investment Managers · as of 2026-03-310,00 %$4M
- Funds · as of 2026-03-310,00 %$5M
- Investment Managers · as of 2026-03-310,00 %$1M
- Investment Managers · as of 2026-03-310,00 %$2M
- Investment Managers · as of 2026-03-310,00 %$1M
- Institutional Investor · as of 2026-03-310,00 %$1M
- Investment Managers · as of 2026-03-310,00 %$2M
- Brokerage Firms · as of 2026-03-310,00 %$1M
- Investment Managers · as of 2026-03-310,00 %$0M
- Investment Managers · as of 2026-03-310,00 %$0M
- Institutional Investor · as of 2026-03-310,00 %$0M
- Institutional Investor · as of 2026-03-310,00 %$0M
Insider activity
- Director · Common stockOther 1 447 · 2026-07-08
- Chief Medical Officer · Common stockOther 8 375 · 2026-07-01
- Chief Medical Officer · Common stockSold 4 007 @ $37,56$151K · 2026-07-01
- Director · Common stockOther 2 816 · 2026-06-18
- Director · Common stockOther 2 816 · 2026-06-18
- Director · Common stockOther 2 816 · 2026-06-18
- Director · Common stockOther 2 816 · 2026-06-18
- Director · Common stockOther 2 816 · 2026-06-18
- Director · Common stockOther 2 816 · 2026-06-18
- Director · Common stockOther 2 816 · 2026-06-18
- Director · Common stockOther 2 816 · 2026-06-18
- Director · Common stockOther 1 976 · 2026-06-13
- Director · Common stockOther 1 976 · 2026-06-13
- Chief Legal Officer · Common stockSold 3 280 @ $34,71$114K · 2026-04-02
- Chief Medical Officer · Common stockOther 8 500 · 2026-04-02
- Chief Medical Officer · Common stockSold 2 940 @ $34,71$102K · 2026-04-02
- Chief Financial Officer · Common stockOther 8 500 · 2026-04-02
- Chief Financial Officer · Common stockSold 3 141 @ $34,71$109K · 2026-04-02
- Chief Commercial Officer · Common stockOther 8 500 · 2026-04-02
- Chief Commercial Officer · Common stockSold 3 262 @ $34,71$113K · 2026-04-02
- Chief Corp Dev & Strategy · Common stockOther 8 100 · 2026-04-02
- Chief Corp Dev & Strategy · Common stockSold 2 959 @ $34,71$103K · 2026-04-02
- Director, Chief Executive Officer · Common stockOther 25 528 · 2026-04-02
- Director, Chief Executive Officer · Common stockSold 12 472 @ $34,71$433K · 2026-04-02
- Director, Chief Executive Officer · Common stockSold 6 596 @ $34,71$229K · 2026-04-02
Short positioning
Geographic breakdown
Intel & risk
Evidence & claims
From filings & derived data- Capex (annual): USD 4.32MUnknown
- R&D expense (annual): USD 339.54MUnknown
- Total liabilities (annual): USD 104.11MUnknown
- Total assets (annual): USD 1.3BUnknown
- Pre-tax income (annual): USD -413.8MUnknown
- Shareholders' equity (annual): USD 1.19BUnknown
- Cash & equivalents (annual): USD 89.13MUnknown
- Current assets (annual): USD 942.05MUnknown
- Current liabilities (annual): USD 82.21MUnknown
- Shares outstanding (annual): 58.45MUnknown
- EPS (diluted) (annual): USD-PER-SHARES -7Unknown
- Operating cash flow (annual): USD -372.98MUnknown
- Revenue (annual): USD 54.03MUnknown
- Operating income (annual): USD -472.13MUnknown
- Cost of revenue (annual): USD 6.34MUnknown
- Net income (annual): USD -413MUnknown
- EPS (basic) (annual): USD-PER-SHARES -7Unknown
- EPS (basic) (annual): USD-PER-SHARES 12Unknown
- R&D expense (annual): USD 301.29MUnknown
- Pre-tax income (annual): USD 717.97MUnknown
- Current liabilities (annual): USD 81.16MUnknown
- Shareholders' equity (annual): USD 1.54BUnknown
- Shares outstanding (annual): 57.16MUnknown
- EPS (diluted) (annual): USD-PER-SHARES 12Unknown