aTyr Pharma Inc
aTyr Pharma Inc is a biotechnology company focused on the discovery and development of novel therapeutics for immune and inflammatory diseases, with a pipeline including clinical-stage programs in dermatology and oncology.
Business. aTyr Pharma Inc (ATYR.O) is a biotechnology company operating within the pharmaceuticals and medical research industry. The firm is headquartered in the United States and is primarily listed on the NASDAQ stock exchange. Specific details regarding its operating segments and geographic revenue mix are not available.
Analyst recommendations
10 analysts · consensus HoldAt a glance
What drives this business
The watch-list the newsroom runs for this company — derived from its sector path, sharpened layer by layer. Not investment advice.
News & coverage
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Upcoming catalysts
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- Company
- EarningsQ3 2026 earnings (expected)2026-10-28 · estimated
- Macro
- Rate decisionBank of England rate decision (press conf.)2026-08-06 · GB
- Rate decisionReserve Bank of Australia rate decision (press conf.)2026-08-12 · AU
- Rate decisionNorges Bank rate decision (press conf.)2026-08-20 · NO
- Rate decisionSveriges Riksbank rate decision (press conf.)2026-09-03 · SE
- Rate decisionBank of Canada rate decision (press conf.)2026-09-09 · CA
- Rate decisionEuropean Central Bank rate decision (press conf.)2026-09-10 · EU
- Macro & political
- ElectionSE Swedish Election2026-09-14 · SE
- ElectionUS U.S. Midterms2026-11-03 · US
- ElectionFR French Legislative2027-06-01 · FR
Pre-earnings brief
Signals & dispatch
Composite-score breakdown
Synthesis
aTyr Pharma Inc (ATYR.O) is a biotechnology company operating within the pharmaceuticals and medical research industry. The firm is headquartered in the United States and is primarily listed on the NASDAQ stock exchange. Specific details regarding its operating segments and geographic revenue mix are not available.
aTyr Pharma maintains a strong liquidity position with a current ratio of 5.3, supported by $10.74 million in cash and equivalents and total assets of $93.00 million. The company's debt-to-equity ratio is 0.01, indicating minimal leverage, and its market cap of $90.38 million is modest relative to its book value of $67.48 million, as reflected in a price-to-book ratio of 1.34.
The company is currently unprofitable, with a net loss of $74.12 million and an operating loss of $77.63 million. Return on equity is -109.84%, and return on assets is -7.97%, both significantly below industry norms for biotechnology firms. The enterprise value to revenue ratio of 423.84 suggests a high valuation relative to its current revenue of $190.00 million, which is driven by a small market cap and no debt.
aTyr Pharma's revenue is concentrated in a single business segment, with no disclosed geographic diversification. The company's operations are entirely focused on the development of therapeutic candidates, with no revenue from commercialized products. This concentration increases exposure to clinical trial outcomes and regulatory delays.
The company's growth trajectory is uncertain, with no revenue growth reported in the latest period. Analysts have issued a wide range of price targets, from $1.00 to $20.00, with a mean of $6.36 and a median of $1.00. The mean recommendation score of 2.60 suggests a mixed outlook, with seven "hold" ratings and only three "buy" or "strong buy" ratings.
aTyr Pharma faces significant financial risk due to its negative operating and free cash flows, which are -$61.99 million and -$73.50 million, respectively. The company has no immediate liquidity or dilution flags, but its capital expenditures of -$77,000 suggest minimal investment in infrastructure. The risk assessment indicates low dilution potential, but the absence of positive cash flows raises concerns about long-term sustainability.
Recent filings and transcripts have not revealed any major events or strategic shifts. The company continues to focus on its clinical pipeline, with no new product launches or partnerships disclosed in the latest period. The lack of recent developments may contribute to the wide dispersion in analyst price targets.
- aTyr Pharma has strong liquidity but is currently unprofitable with significant negative cash flows.
- The company's valuation is highly speculative, with an EV/revenue ratio of 423.84 and no commercialized products.
- Analysts are divided on the stock, with a mean price target of $6.36 but a median of $1.00.
- The company's business is entirely dependent on clinical trial success, with no geographic or segment diversification.
- Despite low dilution risk, the company's financial structure is vulnerable to prolonged negative cash flows.
Bull / Bear case
Generated · model-assistedIn focus — financials by report
Valuation
Revenue by segment
Business relationships
Supply chain
Peer comparison
Market position
Stress test
Predictor forecast
| Metric | Our forecast | Guidance | Consensus |
|---|---|---|---|
| EPS | —no estimate | —no estimate | -0,60 |
| Revenue | —no estimate | —no estimate | 0 USD |
| Operating income | —no estimate | —no estimate | -73,5M USD |
Options
Short squeeze
Earnings-call key lines
Consensus distribution
sell-side coverageEstimate revisions
consensus EPS · 26-week trendSell-side observations
Themes
ESG
Risk factors
- No immediate filing-based liquidity or dilution flags were detected.
Benchmarks vs cohort
Corporate actions / M&A
FX exposure
Comparable transactions
Derivatives & instruments
Derivative transactions
- Director · Stock Option (right to buy) → Common StockAcquired 50 000 @ $0,95grant · 2026-05-11
- Director · Stock Option (right to buy) → Common StockAcquired 50 000 @ $0,95grant · 2026-05-11
- Director · Stock Option (right to buy) → Common StockAcquired 50 000 @ $0,95grant · 2026-05-11
- Director · Stock Option (right to buy) → Common StockAcquired 50 000 @ $0,95grant · 2026-05-11
- Director · Stock Option (right to buy) → Common StockAcquired 50 000 @ $0,95grant · 2026-05-11
- Director · Stock Option (right to buy) → Common StockAcquired 50 000 @ $0,95grant · 2026-05-11
- Director, President and CEO · Restricted Stock Unit → Common StockDisposed 10 375exercise · 2026-02-03
- Chief Financial Officer · Restricted Stock Unit → Common StockDisposed 3 750exercise · 2026-02-03
- General Counsel · Restricted Stock Unit → Common StockDisposed 2 687exercise · 2026-02-03
- Director, President and CEO · Employee Stock Option (right to buy) → Common StockAcquired 1 500 000 @ $0,71grant · 2026-01-09
- Chief Financial Officer · Employee Stock Option (right to buy) → Common StockAcquired 412 500 @ $0,71grant · 2026-01-09
- General Counsel · Employee Stock Options (right to buy) → Common StockAcquired 412 500 @ $0,71grant · 2026-01-09
Actions
Ask Handelsavisen
- Market data
- Market data cache
- Issuer disclosures
- Public news
- Earnings transcripts
- Consensus estimates
- ESG data
- Return On Equitynet_income / total_equity
- Price To Bookmarket_price / (adjusted_book_value / shares_outstanding_diluted)
- Dilution Ratio(shares_outstanding_diluted - shares_outstanding_basic) / shares_outstanding_basic
- Market Priceinput from market-data provider (delayed close or quote-shim mid)
- Market Capmarket_price * shares_outstanding_diluted
- Ev To Revenueenterprise_value / revenue
- aTyr Pharma Inc Market data — financials · 2026-05-27
- aTyr Pharma Inc Market data — analyst estimates · 2026-05-27
Ownership & reference
Top holders
- Institutional Investor · as of 2026-03-310,00 %$11M
- Investment Managers · as of 2026-03-310,00 %$3M
- Investment Managers · as of 2026-03-310,00 %$0M
- Investment Managers · as of 2026-03-310,00 %$2M
- Investment Managers · as of 2026-03-310,00 %$1M
- Investment Managers · as of 2026-03-310,00 %$1M
- Investment Managers · as of 2025-12-310,00 %$4M
- Investment Managers · as of 2024-06-300,00 %$2M
- Investment Managers · as of 2026-03-310,00 %$1M
- Investment Managers · as of 2026-03-310,00 %$0M
- Investment Managers · as of 2026-03-310,00 %$0M
- Institutional Investor · as of 2026-03-310,00 %$0M
- Investment Managers · as of 2026-03-310,00 %$0M
- Investment Managers · as of 2026-03-310,00 %$0M
- Investment Managers · as of 2026-03-310,00 %$0M
- Investment Managers · as of 2026-03-310,00 %$0M
- Brokerage Firms · as of 2026-03-310,00 %$0M
- Funds · as of 2026-03-310,00 %$0M
- Investment Managers · as of 2026-03-310,00 %$0M
- Brokerage Firms · as of 2026-03-310,00 %$0M
- Investment Managers · as of 2026-03-310,00 %$0M
- Institutional Investor · as of 2026-03-310,00 %$0M
Leadership
- Sanjay S ShuklaPresident, Chief Executive Officer, Director
Insider activity
- Director · Common StockBought 100 000 @ $0,50$50K · 2026-05-27
- General Counsel · Common StockSold 1 118 @ $0,98$1K · 2026-02-04
- Director, President and CEO · Common StockSold 3 745 @ $0,98$4K · 2026-02-04
- Chief Financial Officer · Common StockSold 1 558 @ $0,98$2K · 2026-02-04
- Chief Financial Officer · Common StockOther 3 750 · 2026-02-03
- General Counsel · Common StockOther 2 687 · 2026-02-03
- Director, President and CEO · Common StockOther 10 375 · 2026-02-03
- Director · Common StockBought 317 999 @ $0,94$299K · 2025-10-09
- Director · Common StockBought 682 001 @ $0,90$612K · 2025-10-08
Short positioning
Geographic breakdown
Intel & risk
Evidence & claims
From filings & derived data- Return on assets (FY 2025-12-31): -79.7%Derived (calculated)
- Cash & equivalents (YoY) (2025-12-31 vs 2024-12-31): -2.8%Derived (calculated)
- Total assets (YoY) (2025-12-31 vs 2024-12-31): -4.0%Derived (calculated)
- Current ratio (FY 2025-12-31): 5.30xDerived (calculated)
- Capex (YoY) (2025-12-31 vs 2024-12-31): 18.5%Derived (calculated)
- Operating income (YoY) (2025-12-31 vs 2024-12-31): -14.3%Derived (calculated)
- Revenue (YoY) (2025-12-31 vs 2024-12-31): -19.1%Derived (calculated)
- Shareholders' equity (YoY) (2025-12-31 vs 2024-12-31): -3.6%Derived (calculated)
- Operating cash flow (YoY) (2025-12-31 vs 2024-12-31): 10.3%Derived (calculated)
- EPS (diluted) (YoY) (2025-12-31 vs 2024-12-31): 7.0%Derived (calculated)
- Net income (YoY) (2025-12-31 vs 2024-12-31): -15.8%Derived (calculated)
- EPS (basic) (YoY) (2025-12-31 vs 2024-12-31): 7.0%Derived (calculated)
- R&D expense (YoY) (2025-12-31 vs 2024-12-31): 10.8%Derived (calculated)
- Net margin (FY 2025-12-31): -39,009.5%Derived (calculated)
- Return on equity (FY 2025-12-31): -109.8%Derived (calculated)
- Cash & equivalents (annual): USD 10.74MSEC XBRL filing
- Operating cash flow (annual): USD -61.99MSEC XBRL filing
- Shareholders' equity (annual): USD 67.48MSEC XBRL filing
- Capex (annual): USD 77KSEC XBRL filing
- Total operating expenses (annual): USD 77.82MSEC XBRL filing
- Net income (annual): USD -74.12MSEC XBRL filing
- Operating income (annual): USD -77.63MSEC XBRL filing
- EPS (diluted) (annual): USD-PER-SHARES -1SEC XBRL filing
- R&D expense (annual): USD 60.22MSEC XBRL filing