Clene Inc
Clene Inc is a biotechnology company focused on developing therapies for neurodegenerative diseases, including Parkinson's disease and multiple sclerosis.
Business. Clene Inc (CLNN.O) is a biotechnology and medical research company listed on the NASDAQ. The firm operates within the healthcare sector, focusing on pharmaceuticals and medical research activities. No specific operating segments or geographic breakdowns are provided in the available data. The company is headquartered in the United States.
Analyst recommendations
6 analysts · consensus BuyAt a glance
What drives this business
The watch-list the newsroom runs for this company — derived from its sector path, sharpened layer by layer. Not investment advice.
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- Company
- EarningsQ3 2026 earnings (expected)2026-10-28 · estimated
- Macro
- Rate decisionBank of England rate decision (press conf.)2026-08-06 · GB
- Rate decisionReserve Bank of Australia rate decision (press conf.)2026-08-12 · AU
- Rate decisionNorges Bank rate decision (press conf.)2026-08-20 · NO
- Rate decisionSveriges Riksbank rate decision (press conf.)2026-09-03 · SE
- Rate decisionBank of Canada rate decision (press conf.)2026-09-09 · CA
- Rate decisionEuropean Central Bank rate decision (press conf.)2026-09-10 · EU
- Macro & political
- ElectionSE Swedish Election2026-09-14 · SE
- ElectionUS U.S. Midterms2026-11-03 · US
- ElectionFR French Legislative2027-06-01 · FR
Pre-earnings brief
Signals & dispatch
Composite-score breakdown
Synthesis
Clene Inc (CLNN.O) is a biotechnology and medical research company listed on the NASDAQ. The firm operates within the healthcare sector, focusing on pharmaceuticals and medical research activities. No specific operating segments or geographic breakdowns are provided in the available data. The company is headquartered in the United States.
Clene Inc has a market capitalization of $83.04 million and a price-to-book ratio of 19.47, indicating a high valuation relative to its book value. The company's liquidity position is characterized by a current ratio of 1.23, suggesting it has sufficient short-term assets to cover its short-term liabilities, but not by a large margin. The debt-to-equity ratio of 6.36 indicates a high level of leverage, with long-term debt amounting to $27.12 million against total equity of $4.26 million.
The company's profitability is weak, with a net loss of $11.08 million and an operating loss of $9.23 million. Return on equity is negative at -2.5985, and return on assets is also negative at -0.2458, indicating that the company is not generating returns that exceed its cost of capital. Gross profit of $57.00 million is offset by high operating expenses, leading to a significant net loss.
Clene Inc's revenue is concentrated in a single business segment, as disclosed in its financial statements, with no geographic diversification provided in the available data. The company's revenue of $73.00 million is modest, and there is no indication of multiple revenue streams or geographic regions contributing to this figure.
Looking ahead, the company is expected to continue facing financial challenges. The operating cash flow is negative at $7.08 million, and free cash flow is also negative at $10.67 million. Capital expenditures are minimal at $11,000, suggesting limited investment in physical assets. The company's outlook for the current fiscal year is not explicitly provided, but the negative cash flows and high debt levels indicate a challenging growth trajectory.
The risk assessment for Clene Inc highlights medium liquidity risk and low dilution risk. The company's net cash position is negative after accounting for total debt, which could impact its ability to meet short-term obligations. The dilution risk is low, with no significant dilution potential identified in the basic shares outstanding. The company's high leverage and negative cash flows are key risk factors that could affect its financial stability.
Recent events and disclosures indicate that Clene Inc is actively engaged in clinical trials and research and development activities. The company has a mean price target of $30.40 from analysts, with a median price target of $30.00, suggesting a positive outlook from the investment community. However, the high price targets are not supported by current financial performance, and the company has not received any strong-buy recommendations from analysts.
- Clene Inc has a high price-to-book ratio of 19.47, indicating a high valuation relative to its book value.
- The company is highly leveraged, with a debt-to-equity ratio of 6.36, and has a negative net cash position after accounting for total debt.
- Clene Inc is not generating positive returns, with a negative return on equity of -2.5985 and a negative return on assets of -0.2458.
- The company's liquidity position is moderate, with a current ratio of 1.23, but its high debt levels and negative cash flows pose financial risks.
- Analysts have a generally positive outlook, with a mean price target of $30.40, but the company's financial performance does not currently support these expectations.
Bull / Bear case
Generated · model-assistedAnalysts project 421.9% upside to a mean price target of $30.40, signaling strong institutional confidence in future growth.
Free cash flow improved 34.6% year-over-year to -$24.7 million, indicating a meaningful reduction in cash burn rates.
Net income loss narrowed 33.6% year-over-year to -$26.2 million, demonstrating progress in controlling operational expenses relative to prior periods.
Long-term debt decreased to $15.8 million in FY-1, suggesting active balance sheet management and reduced leverage obligations.
Operating income improved 30.7% year-over-year to -$23.1 million, reflecting better cost efficiency despite continued operational losses.
The company carries high credit risk and a debt-to-equity ratio of 6.36, indicating significant financial leverage and solvency concerns.
Net margin of -151.8% ranks in the bottom quartile of the biotechnology cohort, showing extreme profitability inefficiency compared to peers.
A current ratio of 0.83 suggests potential liquidity constraints, as current assets are insufficient to cover short-term liabilities.
Return on equity stands at -2.59, placing the company in the bottom quartile of its peer group for capital efficiency.
In focus — financials by report
Revenue $77.0k, −15,4% YoY; Operating income +15,5% YoY.
- ▍Revenue $77.0k, −15,4% YoY
- ▍Operating income +15,5% YoY
- ▍Net income +31,9% YoY
- ▍Free cash flow +32,3% YoY
- ▍Net margin -11981.8%
Revenue $15.0k, −82,8% YoY; Operating income +27,7% YoY.
- ▍Revenue $15.0k, −82,8% YoY
- ▍Operating income +27,7% YoY
- ▍Net income −9,9% YoY
- ▍Free cash flow −11,1% YoY
- ▍Net margin -58513.3%
Revenue $27.0k, −70,3% YoY; Operating income +20,7% YoY.
- ▍Revenue $27.0k, −70,3% YoY
- ▍Operating income +20,7% YoY
- ▍Net income −9,3% YoY
- ▍Free cash flow −10,7% YoY
- ▍Net margin -27477.8%
Revenue $81.0k, +11,0% YoY; Operating income +55,9% YoY.
- ▍Revenue $81.0k, +11,0% YoY
- ▍Operating income +55,9% YoY
- ▍Net income +93,2% YoY
- ▍Free cash flow +96,8% YoY
- ▍Net margin -927.2%
Revenue $91.0k; Operating income -$8.9M.
- ▍Revenue $91.0k
- ▍Operating income -$8.9M
- ▍Net margin -14889.0%
Revenue $87.0k; Operating income -$7.8M.
- ▍Revenue $87.0k
- ▍Operating income -$7.8M
- ▍Net margin -9179.3%
Revenue $91.0k; Operating income -$7.4M.
- ▍Revenue $91.0k
- ▍Operating income -$7.4M
- ▍Net margin -7456.0%
Revenue $73.0k; Operating income -$9.2M.
- ▍Revenue $73.0k
- ▍Operating income -$9.2M
- ▍Net margin -15178.1%
Revenue $200.0k, −41,5% YoY; Operating income +30,7% YoY.
- ▍Revenue $200.0k, −41,5% YoY
- ▍Operating income +30,7% YoY
- ▍Net income +33,6% YoY
- ▍Free cash flow +34,6% YoY
- ▍Net margin -13086.5%
Revenue $342.0k, −47,7% YoY; Operating income +17,8% YoY.
- ▍Revenue $342.0k, −47,7% YoY
- ▍Operating income +17,8% YoY
- ▍Net income +20,4% YoY
- ▍Free cash flow +21,5% YoY
- ▍Net margin -11520.5%
Revenue $654.0k, +38,3% YoY; Operating income +16,3% YoY.
- ▍Revenue $654.0k, +38,3% YoY
- ▍Operating income +16,3% YoY
- ▍Net income −65,5% YoY
- ▍Free cash flow −41,2% YoY
- ▍Net margin -7569.4%
Revenue $473.0k, −34,6% YoY; Operating income +1,9% YoY.
- ▍Revenue $473.0k, −34,6% YoY
- ▍Operating income +1,9% YoY
- ▍Net income −207,2% YoY
- ▍Free cash flow −236,8% YoY
- ▍Net margin -6325.2%
Valuation TTM
Revenue by segment
Business relationships
Supply chain
Peer comparison
Market position
Stress test
Predictor forecast
| Metric | Our forecast | Guidance | Consensus |
|---|---|---|---|
| EPS | —no estimate | —no estimate | -2,06 |
| Revenue | —no estimate | —no estimate | 230,670 USD |
| Operating income | —no estimate | —no estimate | -30,4M USD |
Options
Short squeeze
Earnings-call key lines
Consensus distribution
sell-side coverageEstimate revisions
consensus EPS · 26-week trendSell-side observations
Themes
ESG
Risk factors
- Net cash is negative after subtracting total debt.
Benchmarks vs cohort
Corporate actions / M&A
FX exposure
Comparable transactions
Derivatives & instruments
Derivative transactions
- Chief Science Officer · stock option → common stockAcquired 45 000 @ $5,53grant · 2026-06-11
- Director, President & CEO · stock option → common stockAcquired 65 000 @ $5,53grant · 2026-06-11
- Chief Financial Officer · stock option → common stockAcquired 15 000 @ $5,53grant · 2026-06-11
- Director · stock option → common stockAcquired 1 500 @ $6,81grant · 2026-05-21
- Director · stock option → common stockAcquired 2 158 @ $6,81grant · 2026-05-21
- Director · stock option → common stockAcquired 1 500 @ $6,81grant · 2026-05-21
- Director · stock option → common stockAcquired 2 861 @ $6,81grant · 2026-05-21
- Director · stock option → common stockAcquired 1 500 @ $6,81grant · 2026-05-21
- Director · stock option → common stockAcquired 3 659 @ $6,81grant · 2026-05-21
- Director · stock option → common stockAcquired 1 500 @ $6,81grant · 2026-05-21
- Director · stock option → common stockAcquired 2 791 @ $6,81grant · 2026-05-21
- Director · stock option → common stockAcquired 1 500 @ $6,81grant · 2026-05-21
- Director · stock option → common stockAcquired 1 500 @ $6,81grant · 2026-05-21
- Director · stock option → common stockAcquired 1 500 @ $6,81grant · 2026-05-21
- Director · stock option → common stockAcquired 2 064 @ $6,81grant · 2026-05-21
- Director · stock option → common stockAcquired 1 876 @ $6,81grant · 2026-05-21
- Director · stock option → common stockAcquired 1 500 @ $6,81grant · 2026-05-21
- Director · stock option → common stockAcquired 2 228 @ $6,81grant · 2026-05-21
- Director · stock option → common stockAcquired 2 064 @ $6,81grant · 2026-05-21
- Director · stock option → common stockAcquired 3 306 @ $4,73grant · 2026-02-19
- Director · stock option → common stockAcquired 3 030 @ $4,73grant · 2026-02-19
- Director · stock option → common stockAcquired 4 201 @ $4,73grant · 2026-02-19
- Director · stock option → common stockAcquired 5 372 @ $4,73grant · 2026-02-19
- Director · stock option → common stockAcquired 3 168 @ $4,73grant · 2026-02-19
Actions
Ask Handelsavisen
- Market data
- Market data cache
- Issuer disclosures
- Public news
- Earnings transcripts
- Consensus estimates
- ESG data
- Return On Equitynet_income / total_equity
- Price To Bookmarket_price / (adjusted_book_value / shares_outstanding_diluted)
- Dilution Ratio(shares_outstanding_diluted - shares_outstanding_basic) / shares_outstanding_basic
- Market Priceinput from market-data provider (delayed close or quote-shim mid)
- Market Capmarket_price * shares_outstanding_diluted
- Ev To Revenueenterprise_value / revenue
- Clene Inc Market data — financials · 2026-05-27
- Clene Inc Market data — analyst estimates · 2026-05-27
- Clene Inc Market data — ESG · 2026-05-27
Ownership & reference
Top holders
- Investment Managers · as of 2026-03-310,00 %$0M
- Investment Managers · as of 2025-12-310,00 %$1M
- Institutional Investor · as of 2026-03-310,00 %$0M
- Investment Managers · as of 2026-03-310,00 %$0M
- Investment Managers · as of 2026-03-310,00 %$0M
- Investment Managers · as of 2026-03-310,00 %$0M
- Brokerage Firms · as of 2026-03-310,00 %$0M
- Investment Managers · as of 2026-03-310,00 %$0M
- Investment Managers · as of 2026-03-310,00 %$0M
- Investment Managers · as of 2024-06-300,00 %$0M
Leadership
- Robert EtheringtonPresident, Chief Executive Officer, Director
Insider activity
- 10% owner · Common StockSold 73 296 @ $6,20$454K · 2026-05-12
- 10% owner · Common StockSold 22 177 @ $6,75$150K · 2026-05-11
- 10% owner · Common StockSold 72 884 @ $6,80$496K · 2026-05-04
- 10% owner · Common StockSold 5 795 @ $6,01$35K · 2026-05-01
- 10% owner · Common StockSold 5 736 @ $6,08$35K · 2026-04-30
- 10% owner · Common StockSold 12 170 @ $5,63$69K · 2026-04-29
- 10% owner · Common StockSold 1 591 @ $5,90$9K · 2026-04-28
- 10% owner · Common StockSold 61 345 @ $6,14$377K · 2026-04-21
- 10% owner · Common StockSold 4 318 @ $6,12$26K · 2026-04-20
- 10% owner · Common StockSold 25 040 @ $6,43$161K · 2026-04-17
- 10% owner · Common StockSold 7 748 @ $6,40$50K · 2026-04-16
- 10% owner · Common StockSold 6 374 @ $6,48$41K · 2026-04-15
- 10% owner · Common StockSold 24 925 @ $4,81$120K · 2026-04-02
- 10% owner · Common StockSold 4 278 @ $4,97$21K · 2026-04-01
- 10% owner · Common StockSold 67 991 @ $4,88$332K · 2026-03-31
- 10% owner · Common StockSold 15 536 @ $5,10$79K · 2026-03-30
- 10% owner · Common StockSold 17 470 @ $4,75$83K · 2026-03-27
- 10% owner · Common StockSold 5 319 @ $5,40$29K · 2026-03-26
- 10% owner · Common StockSold 7 098 @ $5,50$39K · 2026-03-25
- 10% owner · Common StockSold 5 492 @ $5,78$32K · 2026-03-24
Short positioning
Geographic breakdown
Intel & risk
Evidence & claims
From filings & derived data- Total liabilities (YoY) (2025-12-31 vs 2024-12-31): -1.3%Derived (calculated)
- Total assets (YoY) (2025-12-31 vs 2024-12-31): -33.7%Derived (calculated)
- Shareholders' equity (YoY) (2025-12-31 vs 2024-12-31): -98.6%Derived (calculated)
- Return on assets (FY 2025-12-31): -144.4%Derived (calculated)
- R&D expense (YoY) (2025-12-31 vs 2024-12-31): -30.1%Derived (calculated)
- Operating income (YoY) (2025-12-31 vs 2024-12-31): 30.2%Derived (calculated)
- Operating cash flow (YoY) (2025-12-31 vs 2024-12-31): 13.0%Derived (calculated)
- Net income (YoY) (2025-12-31 vs 2024-12-31): 33.6%Derived (calculated)
- Cash & equivalents (YoY) (2025-12-31 vs 2024-12-31): -57.3%Derived (calculated)
- Capex (YoY) (2025-12-31 vs 2024-12-31): 160.0%Derived (calculated)
- Debt-to-equity (FY 2025-12-31): -2.03xDerived (calculated)
- Current ratio (FY 2025-12-31): 0.83xDerived (calculated)
- Revenue (YoY) (2025-12-31 vs 2024-12-31): -41.5%Derived (calculated)
- Net margin (FY 2025-12-31): -13,086.5%Derived (calculated)
- Return on equity (FY 2025-12-31): 148.8%Derived (calculated)
- EPS (basic) (YoY) (2025-12-31 vs 2024-12-31): 53.3%Derived (calculated)
- Cost of revenue (YoY) (2025-12-31 vs 2024-12-31): -38.6%Derived (calculated)
- Long-term debt (annual): USD 17.79MSEC XBRL filing
- Total liabilities (annual): USD 35.72MSEC XBRL filing
- Cash & equivalents (annual): USD 5.19MSEC XBRL filing
- EPS (basic) (annual): USD-PER-SHARES -3SEC XBRL filing
- Cost of revenue (annual): USD 43KSEC XBRL filing
- Pre-tax income (annual): USD -26.17MSEC XBRL filing
- Revenue (annual): USD 200KSEC XBRL filing