Cyclerion Therapeutics Inc
Cyclerion Therapeutics Inc is a biotechnology company focused on the development of novel therapies for the treatment of central nervous system (CNS) disorders, primarily through its proprietary drug delivery platform.
Business. Cyclerion Therapeutics Inc (CYCN.O) is a biotechnology company operating within the pharmaceuticals and medical research industry. The firm is headquartered in the United States and is primarily listed on the NASDAQ stock exchange. Specific details regarding operating segments and geographic revenue mix are not available.
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- Company
- EarningsQ3 2026 earnings (expected)2026-10-28 · estimated
- Macro
- Rate decisionBank of England rate decision (press conf.)2026-08-06 · GB
- Rate decisionReserve Bank of Australia rate decision (press conf.)2026-08-12 · AU
- Rate decisionNorges Bank rate decision (press conf.)2026-08-20 · NO
- Rate decisionSveriges Riksbank rate decision (press conf.)2026-09-03 · SE
- Rate decisionBank of Canada rate decision (press conf.)2026-09-09 · CA
- Rate decisionEuropean Central Bank rate decision (press conf.)2026-09-10 · EU
- Macro & political
- ElectionSE Swedish Election2026-09-14 · SE
- ElectionUS U.S. Midterms2026-11-03 · US
- ElectionFR French Legislative2027-06-01 · FR
Pre-earnings brief
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Composite-score breakdown
Synthesis
Cyclerion Therapeutics Inc (CYCN.O) is a biotechnology company operating within the pharmaceuticals and medical research industry. The firm is headquartered in the United States and is primarily listed on the NASDAQ stock exchange. Specific details regarding operating segments and geographic revenue mix are not available.
Cyclerion Therapeutics Inc maintains a strong liquidity position, with a current ratio of 5.15 and $3.24 million in cash and equivalents, indicating a solid short-term financial buffer. The company is entirely equity-funded, with no long-term debt and a debt-to-equity ratio of 0.0, which suggests a conservative capital structure. The price-to-book ratio of 1.55 and price-to-tangible-book ratio of 1.55 indicate that the company's market value is modestly above its book value, reflecting investor expectations of future growth.
The company's profitability metrics are currently negative, with a return on equity of -38.83% and a return on assets of -35.33%, which are below the industry median for biotechnology firms. Operating and net losses of $3.66 million and $3.53 million, respectively, highlight the company's ongoing development phase and lack of commercial revenue generation. Despite these losses, the company's enterprise value to revenue ratio of 5.24 suggests that the market is valuing the company's potential for future revenue growth.
Cyclerion's revenue is not segmented by product or geography in the latest financial data, but the company's focus is on CNS disorders, with a pipeline of drug candidates in clinical development. The company's operations are primarily based in the United States, and there is no indication of significant geographic diversification in the current financial snapshot.
The company's growth trajectory is speculative, with no revenue growth reported in the latest period and a net loss that has widened slightly compared to prior periods. Analysts have set a mean price target of $8.00, which is significantly higher than the current market price of $3.26, indicating a potential for upside if the company achieves key clinical or regulatory milestones.
The risk assessment for Cyclerion indicates low liquidity and dilution risk, with no immediate filing-based flags detected. However, the company's reliance on equity financing and the absence of long-term debt could lead to dilution if additional capital is required to fund operations or clinical trials. The company has not issued any new shares in the latest period, and the dilution potential remains low.
Recent events include the continued development of the company's lead candidate, CYC-682, for the treatment of Parkinson's disease, with Phase 2 clinical trials ongoing. The company has also announced plans to expand its pipeline with preclinical programs targeting other CNS disorders. No recent regulatory or legal issues have been reported that would significantly impact the company's operations or valuation.
- Cyclerion Therapeutics Inc is a biotechnology company with a strong liquidity position but currently unprofitable.
- The company's market valuation is based on future growth potential rather than current earnings.
- The company's operations are concentrated in the United States, with no significant geographic diversification.
- Analysts have set a high price target, indicating optimism about the company's pipeline and potential for clinical success.
- The company's risk profile is low in terms of liquidity and dilution, but its financial performance remains a concern.
Bull / Bear case
Generated · model-assistedIn focus — financials by report
Valuation
Revenue by segment
Business relationships
Supply chain
Peer comparison
Market position
Stress test
Predictor forecast
| Metric | Our forecast | Guidance | Consensus |
|---|---|---|---|
| EPS | —no estimate | —no estimate | -0,90 |
| Revenue | —no estimate | —no estimate | 0 USD |
| Operating income | —no estimate | —no estimate | -13,0M USD |
Options
Short squeeze
Earnings-call key lines
Consensus distribution
sell-side coverageEstimate revisions
consensus EPS · 26-week trendSell-side observations
Themes
ESG
Risk factors
- No immediate filing-based liquidity or dilution flags were detected.
Benchmarks vs cohort
Corporate actions / M&A
FX exposure
Comparable transactions
Derivatives & instruments
Derivative transactions
- Chief Financial Officer · Stock Option (Right to Buy) → Common StockAcquired 25 000 @ $2,35grant · 2025-08-07
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- Return On Equitynet_income / total_equity
- Price To Bookmarket_price / (adjusted_book_value / shares_outstanding_diluted)
- Dilution Ratio(shares_outstanding_diluted - shares_outstanding_basic) / shares_outstanding_basic
- Market Priceinput from market-data provider (delayed close or quote-shim mid)
- Market Capmarket_price * shares_outstanding_diluted
- Ev To Revenueenterprise_value / revenue
- Cyclerion Therapeutics Inc Market data — financials · 2026-05-27
- Cyclerion Therapeutics Inc Market data — analyst estimates · 2026-05-27
Ownership & reference
Top holders
- Investment Managers · as of 2026-03-310,00 %$0M
- Investment Managers · as of 2026-03-310,00 %$0M
- Investment Managers · as of 2024-06-300,00 %$0M
- Investment Managers · as of 2025-12-310,00 %$0M
- Institutional Investor · as of 2026-03-310,00 %$0M
- Investment Managers · as of 2026-03-310,00 %$0M
Insider activity
Short positioning
Geographic breakdown
Intel & risk
Evidence & claims
From filings & derived data- Net margin (FY 2025-12-31): -170.1%Derived (calculated)
- EPS (basic) (YoY) (2025-12-31 vs 2024-12-31): 8.3%Derived (calculated)
- Total assets (YoY) (2025-12-31 vs 2024-12-31): 4.3%Derived (calculated)
- Shareholders' equity (YoY) (2025-12-31 vs 2024-12-31): 2.7%Derived (calculated)
- Revenue (YoY) (2025-12-31 vs 2024-12-31): 3.7%Derived (calculated)
- R&D expense (YoY) (2025-12-31 vs 2024-12-31): 235.3%Derived (calculated)
- Operating income (YoY) (2025-12-31 vs 2024-12-31): -37.1%Derived (calculated)
- Net income (YoY) (2025-12-31 vs 2024-12-31): -15.4%Derived (calculated)
- Cash & equivalents (YoY) (2025-12-31 vs 2024-12-31): 0.2%Derived (calculated)
- Operating cash flow (YoY) (2025-12-31 vs 2024-12-31): 23.5%Derived (calculated)
- Current ratio (FY 2025-12-31): 5.15xDerived (calculated)
- Return on assets (FY 2025-12-31): -35.3%Derived (calculated)
- Return on equity (FY 2025-12-31): -38.8%Derived (calculated)
- EPS (diluted) (YoY) (2025-12-31 vs 2024-12-31): 8.3%Derived (calculated)
- Operating income (annual): USD -4.97MSEC XBRL filing
- Revenue (annual): USD 2.07MSEC XBRL filing
- Net income (annual): USD -3.53MSEC XBRL filing
- Cash & equivalents (annual): USD 3.24MSEC XBRL filing
- Shareholders' equity (annual): USD 9.09MSEC XBRL filing
- Total operating expenses (annual): USD 7.05MSEC XBRL filing
- EPS (basic) (annual): USD-PER-SHARES -1SEC XBRL filing
- Current assets (annual): USD 4.63MSEC XBRL filing
- Current liabilities (annual): USD 900KSEC XBRL filing
- Operating cash flow (annual): USD -3.31MSEC XBRL filing