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CYCN.O NASDAQ Pharmaceuticals & Medical Research

Cyclerion Therapeutics Inc

$3,49
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Mcap
15,1M USD
P/E
EV / Rev
Div yield
Op margin
-176,3 %
ROE
-38,8 %
Net margin
-170,1 %
Debt / equity
0,00
Beta
52w range
Volume
163
Day range
$3,06–$3,24
Prev close
$3,20
Open
$3,10
Next earnings
2026-10-28
Ex-dividend
TR 1Y
About

Cyclerion Therapeutics Inc is a biotechnology company focused on the development of novel therapies for the treatment of central nervous system (CNS) disorders, primarily through its proprietary drug delivery platform.

Business. Cyclerion Therapeutics Inc (CYCN.O) is a biotechnology company operating within the pharmaceuticals and medical research industry. The firm is headquartered in the United States and is primarily listed on the NASDAQ stock exchange. Specific details regarding operating segments and geographic revenue mix are not available.

Classification99 %
SectorHealth Care
Industry groupPharmaceuticals & Medical Research
Generated · model-assisted
Sell-side consensus
consensus pending
— buy— hold— sell
Avg 12m price target
Upcoming events
  • EarningsQ3 2026 earnings (expected)2026-10-28 · estimated
See all catalysts →

At a glance

Score
not yet scored
Valuation
valuation pending
Analysts
not yet wired
Ownership
Geode Capital Management, L.L.C.
largest disclosed fund holder
Profitability
-38,8 %
return on equity
Quality
not yet scored

What drives this business

The watch-list the newsroom runs for this company — derived from its sector path, sharpened layer by layer. Not investment advice.

— missing data

News & coverage

0
  • No recent newsroom coverage mentioning CYCN.
  • Sector rotation

    Sector1D1Mvs mkt
    Materials+2,3 %+6,6 %+1,7 %
    Communication Services+2,2 %−5,5 %+1,6 %
    Energy+0,6 %+3,3 %+0,0 %
    Health Care · THIS SECTOR+0,6 %−0,8 %+0,0 %
    Information Technology+0,6 %+6,7 %+0,0 %
    Consumer Discretionary+0,4 %+7,6 %−0,2 %
    Financials−0,3 %−2,8 %−0,9 %
    Consumer Staples−0,4 %+2,5 %−1,0 %
    Real Estate−0,7 %+10,9 %−1,3 %
    Industrials−1,9 %−3,1 %−2,5 %
    Utilities−1,9 %+28,2 %−2,5 %

    Developing storylines

    No tracked sagas currently linked to CYCN.O. Browse all sagas →

    Analysis

    AI analysis
    Generated · analysis pipeline · tier hybrid · as of 2026-08-04 ↑ At a glance

    Opportunity

    — missing data

    Upcoming catalysts

    Scheduled public events. Informational only — not investment advice.

    • Company
    • EarningsQ3 2026 earnings (expected)2026-10-28 · estimated
    • Macro
    • Rate decisionBank of England rate decision (press conf.)2026-08-06 · GB
    • Rate decisionReserve Bank of Australia rate decision (press conf.)2026-08-12 · AU
    • Rate decisionNorges Bank rate decision (press conf.)2026-08-20 · NO
    • Rate decisionSveriges Riksbank rate decision (press conf.)2026-09-03 · SE
    • Rate decisionBank of Canada rate decision (press conf.)2026-09-09 · CA
    • Rate decisionEuropean Central Bank rate decision (press conf.)2026-09-10 · EU
    • Macro & political
    • ElectionSE Swedish Election2026-09-14 · SE
    • ElectionUS U.S. Midterms2026-11-03 · US
    • ElectionFR French Legislative2027-06-01 · FR

    Pre-earnings brief

    — missing data

    Signals & dispatch

    peak dispatch · —

    Composite-score breakdown

    Synthesis

    Business

    Cyclerion Therapeutics Inc (CYCN.O) is a biotechnology company operating within the pharmaceuticals and medical research industry. The firm is headquartered in the United States and is primarily listed on the NASDAQ stock exchange. Specific details regarding operating segments and geographic revenue mix are not available.

    Classification99 %
    SectorHealth Care
    Industry groupPharmaceuticals & Medical Research
    AI synthesis
    GENERATED

    Cyclerion Therapeutics Inc maintains a strong liquidity position, with a current ratio of 5.15 and $3.24 million in cash and equivalents, indicating a solid short-term financial buffer. The company is entirely equity-funded, with no long-term debt and a debt-to-equity ratio of 0.0, which suggests a conservative capital structure. The price-to-book ratio of 1.55 and price-to-tangible-book ratio of 1.55 indicate that the company's market value is modestly above its book value, reflecting investor expectations of future growth.

    The company's profitability metrics are currently negative, with a return on equity of -38.83% and a return on assets of -35.33%, which are below the industry median for biotechnology firms. Operating and net losses of $3.66 million and $3.53 million, respectively, highlight the company's ongoing development phase and lack of commercial revenue generation. Despite these losses, the company's enterprise value to revenue ratio of 5.24 suggests that the market is valuing the company's potential for future revenue growth.

    Cyclerion's revenue is not segmented by product or geography in the latest financial data, but the company's focus is on CNS disorders, with a pipeline of drug candidates in clinical development. The company's operations are primarily based in the United States, and there is no indication of significant geographic diversification in the current financial snapshot.

    The company's growth trajectory is speculative, with no revenue growth reported in the latest period and a net loss that has widened slightly compared to prior periods. Analysts have set a mean price target of $8.00, which is significantly higher than the current market price of $3.26, indicating a potential for upside if the company achieves key clinical or regulatory milestones.

    The risk assessment for Cyclerion indicates low liquidity and dilution risk, with no immediate filing-based flags detected. However, the company's reliance on equity financing and the absence of long-term debt could lead to dilution if additional capital is required to fund operations or clinical trials. The company has not issued any new shares in the latest period, and the dilution potential remains low.

    Recent events include the continued development of the company's lead candidate, CYC-682, for the treatment of Parkinson's disease, with Phase 2 clinical trials ongoing. The company has also announced plans to expand its pipeline with preclinical programs targeting other CNS disorders. No recent regulatory or legal issues have been reported that would significantly impact the company's operations or valuation.

    Key takeaways
    • Cyclerion Therapeutics Inc is a biotechnology company with a strong liquidity position but currently unprofitable.
    • The company's market valuation is based on future growth potential rather than current earnings.
    • The company's operations are concentrated in the United States, with no significant geographic diversification.
    • Analysts have set a high price target, indicating optimism about the company's pipeline and potential for clinical success.
    • The company's risk profile is low in terms of liquidity and dilution, but its financial performance remains a concern.

    Bull / Bear case

    Generated · model-assisted
    — missing data

    In focus — financials by report

    Valuation

    Market price
    $3,49
    Market cap
    $14.1M
    Enterprise value
    $10.9M
    P/E
    Non-GAAP P/E
    EV / Revenue
    EV / Op income
    EV / OCF
    P / B
    1.6x
    P / Tangible book
    1.6x
    Tangible book
    $9.1M
    Net cash
    $3.2M
    Current ratio
    5.2
    Debt / equity
    0.0
    ROA
    -35.3%
    ROE
    -38.8%
    Cash conversion
    94.0%
    CapEx / revenue
    SBC / revenue
    Dilution ratio
    0.0%

    Revenue by segment

    Market share

    INDUSTRYSEGMENTCOMPANYHealthcareIndustryPharmaceuticals & Medical Research15,2B node revenueKLAR 23,0%BNTX 21,4%EXEL 15,2%MDGL 6,3%INSM 4,0%VCYT 3,4%MDXG 2,8%AVIR 2,3%Other 21,6%
    Source: company disclosures · own-taxonomy revenue-covered setCYCN 0,0% · rank #65 of 109

    Business relationships

    — missing data

    Supply chain

    — missing data

    Peer comparison

    Peer comparison8 peers · vs CYCN · multiples and returns
    KL
    KLAR
    KLAR.ST
    P/E
    vs self
    Div yield
    vs self
    ROE
    vs self
    BN
    BNTX
    Biontech SE
    $92,25
    23,3B USD
    P/E
    vs self
    Div yield
    vs self
    ROE
    vs self
    EX
    EXEL
    Exelixis Inc
    $55,06
    14,7B USD
    P/E
    19,5x
    vs self
    Div yield
    vs self
    ROE
    40,4 %
    +79,3 vs self
    MD
    MDGL
    Madrigal Pharmaceuticals Inc
    $482,00
    11,0B USD
    P/E
    vs self
    Div yield
    vs self
    ROE
    -47,8 %
    -9,0 vs self
    IN
    INSM
    Insmed Inc
    $107,46
    23,0B USD
    P/E
    vs self
    Div yield
    vs self
    ROE
    -160,2 %
    -121,4 vs self
    VC
    VCYT
    Veracyte Inc
    $45,30
    3,6B USD
    P/E
    55,5x
    vs self
    Div yield
    vs self
    ROE
    5,1 %
    +43,9 vs self
    MD
    MDXG
    Mimedx Group Inc
    $4,27
    636,0M USD
    P/E
    11,1x
    vs self
    Div yield
    vs self
    ROE
    18,9 %
    +57,8 vs self
    AV
    AVIR
    Atea Pharmaceuticals Inc
    $4,61
    P/E
    vs self
    Div yield
    vs self
    ROE
    -57,5 %
    -18,7 vs self

    Market position

    Stress test

    — missing data

    Predictor forecast

    Next quarternear-term
    Earnings · next quarterconf 45 %
    EPS
    Consensus EPS
    -0,90
    Predicted surprise
    0,00
    Beat probability
    45 %
    Analysts
    Other metrics
    Revenue
    no estimate
    Segment revenue
    no estimate
    Margin
    no estimate
    Segment margin
    no estimate
    as of 2026-05-04 · Earnings Surprise V1
    Period note: consensus is not fiscal-period-aligned at source — read as consensus vs the last reported actual, not a calibrated same-quarter surprise.
    Full fiscal year~1 year ahead
    Full fiscal year · our forecast vs guidance vs consensus
    MetricOur forecastGuidanceConsensus
    EPSno estimateno estimate-0,90
    Revenueno estimateno estimate0 USD
    Operating incomeno estimateno estimate-13,0M USD
    Full-year consensus mean (period as reported by source) · consensus in USD. Company-level full-year forecast and management guidance are not yet modelled at scale — shown as "no estimate", never inferred.
    Probabilistic model output — not investment advice. · generated 2026-08-04

    Options

    — missing data

    Short squeeze

    — missing data

    Earnings-call key lines

    — missing data

    Consensus distribution

    sell-side coverage
    12-month price target$8,00 · Median $8,00
    Low $8,00High $8,00
    Operating income · consensus-13,0M USD
    EPS surprise
    −23,3 %
    reported vs consensus · miss

    Estimate revisions

    consensus EPS · 26-week trend
    — missing data

    Sell-side observations

    Low$8,00
    Mean$8,00
    Median$8,00
    High$8,00
    Spot$3,49
    +129.2 %implied to mean12-month sell-side price targets · ▲ spot

    Themes

    — missing data

    ESG

    — missing data

    Risk factors

    Dilution riskLow
    Liquidity riskLow
    Filing-based flags
    • No immediate filing-based liquidity or dilution flags were detected.

    Benchmarks vs cohort

    Op Margin-176,3 %Above median
    Net Margin-170,1 %Above median
    ROE-38,8 %Below median
    D/E0,00Above median
    Cash Conv0,94Above median

    Corporate actions / M&A

    — missing data

    FX exposure

    — missing data

    Comparable transactions

    — missing data

    Derivatives & instruments

    Derivative transactions

    Net acquired 25 000 sh1 grants1 insiders
    • CHICKO RHONDA M.Chief Financial Officer · Stock Option (Right to Buy) → Common StockAcquired 25 000 @ $2,35grant · 2025-08-07

    Actions

    Ask Handelsavisen

    — missing data
    Data sources
    • Market data
    • Market data cache
    • Issuer disclosures
    • Public news
    • Earnings transcripts
    • Consensus estimates
    • ESG data
    How metrics are computed
    • Return On Equity
      net_income / total_equity
    • Price To Book
      market_price / (adjusted_book_value / shares_outstanding_diluted)
    • Dilution Ratio
      (shares_outstanding_diluted - shares_outstanding_basic) / shares_outstanding_basic
    • Market Price
      input from market-data provider (delayed close or quote-shim mid)
    • Market Cap
      market_price * shares_outstanding_diluted
    • Ev To Revenue
      enterprise_value / revenue
    Source documents
    • Cyclerion Therapeutics Inc Market data — financials · 2026-05-27
    • Cyclerion Therapeutics Inc Market data — analyst estimates · 2026-05-27

    Ownership & reference

    Top holders

    • Geode Capital Management, L.L.C.Investment Managers · as of 2026-03-310,00 %$0M
    • UBS Financial Services, Inc.Investment Managers · as of 2026-03-310,00 %$0M
    • BlackRock Institutional Trust Company, N.A.Investment Managers · as of 2024-06-300,00 %$0M
    • Vanguard Capital Management, LLCInvestment Managers · as of 2025-12-310,00 %$0M
    • FMR LLCInstitutional Investor · as of 2026-03-310,00 %$0M
    • Morgan Stanley Smith Barney LLCInvestment Managers · as of 2026-03-310,00 %$0M

    Insider activity

    — missing data

    Short positioning

    34.8Kshares short-30.3% vs prior
    1.34days to cover
    27.5%short of daily vol
    12.4Kfails-to-deliver
    as of 2026-07-15 · short-interest report (free)

    Geographic breakdown

    — missing data
    Listings · one canonical issuer all listings resolve to the canonical
    CYCN.OCanonical
    NASDAQ · USD

    Intel & risk

    PredictorBeat prob45 %Surprise0,00Full forecast →
    peak dispatch · —
    OSINT findings
    Dilution riskLow
    Liquidity riskLow
    No immediate filing-based liquidity or dilution flags were detected.

    Evidence & claims

    From filings & derived data
    • Net margin (FY 2025-12-31): -170.1%Derived (calculated)
    • EPS (basic) (YoY) (2025-12-31 vs 2024-12-31): 8.3%Derived (calculated)
    • Total assets (YoY) (2025-12-31 vs 2024-12-31): 4.3%Derived (calculated)
    • Shareholders' equity (YoY) (2025-12-31 vs 2024-12-31): 2.7%Derived (calculated)
    • Revenue (YoY) (2025-12-31 vs 2024-12-31): 3.7%Derived (calculated)
    • R&D expense (YoY) (2025-12-31 vs 2024-12-31): 235.3%Derived (calculated)
    • Operating income (YoY) (2025-12-31 vs 2024-12-31): -37.1%Derived (calculated)
    • Net income (YoY) (2025-12-31 vs 2024-12-31): -15.4%Derived (calculated)
    • Cash & equivalents (YoY) (2025-12-31 vs 2024-12-31): 0.2%Derived (calculated)
    • Operating cash flow (YoY) (2025-12-31 vs 2024-12-31): 23.5%Derived (calculated)
    • Current ratio (FY 2025-12-31): 5.15xDerived (calculated)
    • Return on assets (FY 2025-12-31): -35.3%Derived (calculated)
    • Return on equity (FY 2025-12-31): -38.8%Derived (calculated)
    • EPS (diluted) (YoY) (2025-12-31 vs 2024-12-31): 8.3%Derived (calculated)
    • Operating income (annual): USD -4.97MSEC XBRL filing
    • Revenue (annual): USD 2.07MSEC XBRL filing
    • Net income (annual): USD -3.53MSEC XBRL filing
    • Cash & equivalents (annual): USD 3.24MSEC XBRL filing
    • Shareholders' equity (annual): USD 9.09MSEC XBRL filing
    • Total operating expenses (annual): USD 7.05MSEC XBRL filing
    • EPS (basic) (annual): USD-PER-SHARES -1SEC XBRL filing
    • Current assets (annual): USD 4.63MSEC XBRL filing
    • Current liabilities (annual): USD 900KSEC XBRL filing
    • Operating cash flow (annual): USD -3.31MSEC XBRL filing
    Showing 24 of 60 surfaced claims.
    Atomic claims from regulatory filings and derived calculations. Provenance shown as source kind only.

    The Thread

    Everything we know, in order
    2026-10-28EVENTUpcomingQ3 2026 earnings (expected) estimated date
    2026-06-30 03:38 UTCEARNINGSUpcomingForecast: earnings_forecast (90d)
    2026-05-12FILING10-Q filing →
    2026-04-01FILING8-K filing →
    2026-03-30FILING10-K filing →
    2026-02-17FILING8-K filing →
    2026-01-06FILING8-K filing →
    2025-12-01FILING8-K filing →
    2025-11-12FILING10-Q filing →
    2025-09-23FILING8-K filing →
    2025-08-07 00:00 UTCINSIDER1 insider transaction — 2025-08 1 derivative
    2025-08-07INSIDERCHICKO RHONDA M. acquired 25.0k sh Stock Option (Right to Buy) — Chief Financial Officer
    2025-08-05FILING10-Q filing →
    2025-06-18FILING8-K filing →
    2025-05-07FILING8-K filing →
    2025-05-07FILING424B5 filing →
    2025-03-25 00:00 UTCINSIDER2 insider transactions — 2025-03 · net buy $525k
    2024-11-21 00:00 UTCINSIDER1 insider transaction — 2024-11 · net sell $555k
    2024-08-05 00:00 UTCINSIDER1 insider transaction — 2024-08 1 derivative
    2024-01-01 00:00 UTCINSIDER2 insider transactions — 2024-01
    2023-12-01 00:00 UTCINSIDER1 insider transaction — 2023-12
    2023-11-30 00:00 UTCINSIDER5 insider transactions — 2023-11
    2023-08-09 00:00 UTCINSIDER1 insider transaction — 2023-08
    The entity's full life in the product — typed, chronological, joined across Newspaper, Platform and Data. Our memory, made visible.
    Sources filings · IR · transcripts · market data · tier hybrid · as of 2026-08-04 Market data · Issuer disclosures · Public news · Earnings transcripts · Consensus estimates · ESG data Premium coverage