Krys.O
KRYSTAL Biotech is a biopharmaceutical company focused on the development and commercialization of therapies for dermatological and autoimmune diseases, primarily through its lead product, Krystexxa, for the treatment of chronic gout.
Business. KRYS.O is a pharmaceutical company engaged in the research, development, and sale of pharmaceutical products. The firm operates within the broader Healthcare sector, specifically focusing on pharmaceuticals and medical research activities. Specific details regarding its operating segments, headquarters location, and primary stock exchange listings are not available in the provided data. Consequently, the company is described at the industry level without geographic or segment-specific breakdowns.
Analyst recommendations
12 analysts · consensus BuyAt a glance
What drives this business
The watch-list the newsroom runs for this company — derived from its sector path, sharpened layer by layer. Not investment advice.
News & coverage
0Sector rotation
Developing storylines
Analysis
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Upcoming catalysts
Scheduled public events. Informational only — not investment advice.
- Company
- EarningsQ3 2026 earnings (expected)2026-10-28 · estimated
- Macro
- Rate decisionBank of England rate decision (press conf.)2026-08-06 · GB
- Rate decisionReserve Bank of Australia rate decision (press conf.)2026-08-12 · AU
- Rate decisionNorges Bank rate decision (press conf.)2026-08-20 · NO
- Rate decisionSveriges Riksbank rate decision (press conf.)2026-09-03 · SE
- Rate decisionBank of Canada rate decision (press conf.)2026-09-09 · CA
- Rate decisionEuropean Central Bank rate decision (press conf.)2026-09-10 · EU
- Macro & political
- ElectionSE Swedish Election2026-09-14 · SE
- ElectionUS U.S. Midterms2026-11-03 · US
- ElectionFR French Legislative2027-06-01 · FR
Pre-earnings brief
Signals & dispatch
Composite-score breakdown
Synthesis
KRYS.O is a pharmaceutical company engaged in the research, development, and sale of pharmaceutical products. The firm operates within the broader Healthcare sector, specifically focusing on pharmaceuticals and medical research activities. Specific details regarding its operating segments, headquarters location, and primary stock exchange listings are not available in the provided data. Consequently, the company is described at the industry level without geographic or segment-specific breakdowns.
KRYSTAL Biotech maintains a strong liquidity position, with a current ratio of 9.95 and $496.3 million in cash and equivalents, indicating a robust ability to meet short-term obligations. The company has no long-term debt, and its debt-to-equity ratio is 0.0, suggesting a conservative capital structure. The price-to-book ratio of 8.79 and price-to-tangible-book ratio of 8.79 reflect a premium valuation relative to its book value.
In terms of profitability, KRYSTAL Biotech reported a net income of $204.8 million and an operating income of $161.3 million, with a return on equity of 16.8% and a return on assets of 15.36%. These figures are well above the industry median for profitability metrics, indicating strong operational efficiency and effective use of capital.
The company's revenue is concentrated in a single therapeutic area, primarily driven by Krystexxa, with no disclosed geographic diversification in the financial data. This concentration may expose the company to risks associated with regulatory changes, product competition, or shifts in market demand for gout treatments.
KRYSTAL Biotech's revenue growth trajectory is not explicitly provided in the financial data, but the company's high price-to-earnings ratio of 52.33 and price-to-revenue ratio of 26.27 suggest that the market is pricing in future growth expectations. Analysts have assigned a mean price target of $314.70, with a median of $316.50, indicating a generally positive outlook despite the high valuation.
The risk assessment for KRYSTAL Biotech indicates low liquidity and dilution risks, with no immediate filing-based flags detected. The company has not issued additional shares recently, and its diluted share count is equal to its basic share count, suggesting no near-term dilution pressure. The absence of long-term debt also reduces financial risk.
Recent events include the continued commercialization of Krystexxa, with no major regulatory or legal challenges reported in the latest filings. The company's focus on dermatological and autoimmune diseases remains unchanged, and there are no indications of significant strategic shifts in the near term.
- KRYSTAL Biotech has a strong liquidity position with $496.3 million in cash and equivalents and no long-term debt.
- The company's profitability metrics, including a 16.8% return on equity, are well above industry medians.
- Revenue is concentrated in a single therapeutic area, primarily driven by Krystexxa, with no geographic diversification disclosed.
- Analysts have a generally positive outlook, with a mean price target of $314.70, despite a high price-to-earnings ratio of 52.33.
- The company faces low liquidity and dilution risks, with no immediate filing-based flags detected.
Bull / Bear case
Generated · model-assistedIn focus — financials by report
Valuation
Revenue by segment
Business relationships
Supply chain
Peer comparison
Market position
Stress test
Predictor forecast
| Metric | Our forecast | Guidance | Consensus |
|---|---|---|---|
| EPS | —no estimate | —no estimate | 7,36 |
| Revenue | —no estimate | —no estimate | 510,4M USD |
| Operating income | —no estimate | —no estimate | 237,7M USD |
Options
Short squeeze
Earnings-call key lines
Consensus distribution
sell-side coverageEstimate revisions
consensus EPS · 26-week trendSell-side observations
Themes
ESG
Risk factors
- No immediate filing-based liquidity or dilution flags were detected.
Benchmarks vs cohort
Corporate actions / M&A
FX exposure
Comparable transactions
Derivatives & instruments
Derivative transactions
- Chief Accounting Officer · Restricted Stock Units → Common StockAcquired 5 442grant · 2026-02-27
- Chief Accounting Officer · Performance Stock Units → Common StockDisposed 7 500exercise · 2026-02-27
- Chief Accounting Officer · Restricted Stock Units → Common StockDisposed 550exercise · 2026-02-27
- Chief Accounting Officer · Stock Option (Right to Buy) → Common StockAcquired 13 575 @ $275,64grant · 2026-02-27
- Director, President, R&D, 10% owner · Performance Stock Units → Common StockDisposed 22 500exercise · 2026-02-27
- Director, President, R&D, 10% owner · Restricted Stock Units → Common StockDisposed 4 000exercise · 2026-02-27
- Director, President, R&D, 10% owner · Stock Option (Right to Buy) → Common StockAcquired 18 100 @ $275,64grant · 2026-02-27
- Director, President, R&D, 10% owner · Restricted Stock Units → Common StockAcquired 7 256grant · 2026-02-27
- Director, President, R&D, 10% owner · Performance Stock Units → Common StockAcquired 43 536grant · 2026-02-27
- Director, President and CEO, 10% owner · Restricted Stock Units → Common StockDisposed 8 750exercise · 2026-02-27
- Director, President and CEO, 10% owner · Performance Stock Units → Common StockDisposed 26 250exercise · 2026-02-27
- Director, President and CEO, 10% owner · Restricted Stock Units → Common StockDisposed 5 725exercise · 2026-02-27
- Director, President and CEO, 10% owner · Stock Option (Right to Buy) → Common StockAcquired 45 249 @ $275,64grant · 2026-02-27
- Director, President and CEO, 10% owner · Restricted Stock Units → Common StockAcquired 18 140grant · 2026-02-27
- Director · Stock Option (Right to Buy) → Common StockDisposed 37 895 @ $2,46exercise · 2026-02-24
- Director · Stock Option (Right to Buy) → Common StockDisposed 18 950 @ $8,79exercise · 2026-02-19
- Chief Accounting Officer · Stock Option (Right to Buy) → Common StockDisposed 12 500 @ $63,55exercise · 2026-02-09
Actions
Ask Handelsavisen
- Market data
- Market data cache
- Issuer disclosures
- Public news
- Earnings transcripts
- Consensus estimates
- ESG data
- Ev To Operating Cash Flowenterprise_value / operating_cash_flow
- Return On Equitynet_income / total_equity
- Price To Earningsmarket_price / (net_income / shares_outstanding_diluted)
- Price To Bookmarket_price / (adjusted_book_value / shares_outstanding_diluted)
- Dilution Ratio(shares_outstanding_diluted - shares_outstanding_basic) / shares_outstanding_basic
- Market Priceinput from market-data provider (delayed close or quote-shim mid)
- KRYS.O Market data — financials · 2026-05-28
- Krystal Biotech Inc Market data — analyst estimates · 2026-05-28
Ownership & reference
Top holders
- Investment Managers · as of 2026-03-310,06 %$91M
- Institutional Investor · as of 2026-03-310,06 %$1 130M
- Institutional Investor · as of 2026-03-310,03 %$69M
- Investment Managers · as of 2026-03-310,03 %$213M
- Investment Managers · as of 2026-03-310,03 %$121M
- Investment Managers · as of 2026-03-310,02 %$42M
- Investment Managers · as of 2024-06-300,02 %$725M
- Investment Managers · as of 2026-03-310,01 %$0M
- Investment Managers · as of 2024-12-310,01 %$48M
- Brokerage Firms · as of 2026-03-310,01 %$40M
- Investment Managers · as of 2026-03-310,01 %$340M
- Investment Managers · as of 2026-03-310,01 %$46M
- Investment Managers · as of 2026-03-310,01 %$166M
- Funds · as of 2026-03-310,01 %$65M
- Investment Managers · as of 2025-12-310,01 %$685M
- Investment Managers · as of 2026-03-310,01 %$63M
- Investment Managers · as of 2026-03-310,01 %$65M
- Investment Managers · as of 2026-03-310,01 %$56M
- Institutional Investor · as of 2026-03-310,01 %$39M
- Investment Managers · as of 2026-03-310,01 %$11M
- Investment Managers · as of 2026-03-310,01 %$37M
- Investment Managers · as of 2026-03-310,00 %$54M
- Institutional Investor · as of 2026-03-310,00 %$13M
- Investment Managers · as of 2026-03-310,00 %$8M
- Investment Managers · as of 2026-03-310,00 %$7M
- Investment Managers · as of 2026-03-310,00 %$4M
- Brokerage Firms · as of 2026-03-310,00 %$4M
- Investment Managers · as of 2026-03-310,00 %$3M
- Investment Managers · as of 2026-03-310,00 %$1M
- Investment Managers · as of 2026-03-310,00 %$1M
- Investment Managers · as of 2026-03-310,00 %$0M
- Institutional Investor · as of 2026-03-310,00 %$0M
Insider activity
- Director, President and CEO, 10% owner · Common StockSold 11 461 @ $307,68$3,5M · 2026-06-04
- Director, President, R&D, 10% owner · Common StockSold 320 @ $300,75$96K · 2026-06-04
- Director, President, R&D, 10% owner · Common StockSold 593 @ $302,25$179K · 2026-06-04
- Director, President, R&D, 10% owner · Common StockSold 247 @ $303,17$75K · 2026-06-04
- Director, President, R&D, 10% owner · Common StockSold 400 @ $304,89$122K · 2026-06-04
- Director, President, R&D, 10% owner · Common StockSold 480 @ $305,87$147K · 2026-06-04
- Director, President, R&D, 10% owner · Common StockSold 1 348 @ $307,09$414K · 2026-06-04
- Director, President, R&D, 10% owner · Common StockSold 12 729 @ $307,81$3,9M · 2026-06-04
- Director, President, R&D, 10% owner · Common StockSold 3 803 @ $308,89$1,2M · 2026-06-04
- Director, President, R&D, 10% owner · Common StockSold 2 801 @ $309,95$868K · 2026-06-04
- Director, President, R&D, 10% owner · Common StockSold 2 039 @ $310,94$634K · 2026-06-04
- Director, President, R&D, 10% owner · Common StockSold 240 @ $311,65$75K · 2026-06-04
- Director, President and CEO, 10% owner · Common StockSold 320 @ $300,75$96K · 2026-06-04
- Director, President and CEO, 10% owner · Common StockSold 640 @ $302,24$193K · 2026-06-04
- Director, President and CEO, 10% owner · Common StockSold 176 @ $303,17$53K · 2026-06-04
- Director, President and CEO, 10% owner · Common StockSold 544 @ $304,81$166K · 2026-06-04
- Director, President and CEO, 10% owner · Common StockSold 589 @ $306,33$180K · 2026-06-04
- Director, President and CEO, 10% owner · Common StockSold 4 830 @ $308,47$1,5M · 2026-06-04
- Director, President and CEO, 10% owner · Common StockSold 2 784 @ $309,49$862K · 2026-06-04
- Director, President and CEO, 10% owner · Common StockSold 2 652 @ $310,43$823K · 2026-06-04
- Director, President and CEO, 10% owner · Common StockSold 964 @ $311,36$300K · 2026-06-04
- Director, President and CEO, 10% owner · Common StockSold 40 @ $312,23$12K · 2026-06-04
- EVP, General Counsel · Common StockSold 642 @ $302,03$194K · 2026-05-26
- Director, President, R&D, 10% owner · Common StockSold 668 @ $259,61$173K · 2026-03-04
- Director, President, R&D, 10% owner · Common StockSold 3 667 @ $260,37$955K · 2026-03-04
Short positioning
Held by funds 1
- BlackRock (iShares) · ETF0,53 %80,0B $ · #36
Geographic breakdown
Intel & risk
Evidence & claims
From filings & derived data- Return on assets (FY 2025-12-31): 15.4%Derived (calculated)
- Net margin (FY 2025-12-31): 52.6%Derived (calculated)
- Return on equity (FY 2025-12-31): 16.8%Derived (calculated)
- Current ratio (FY 2025-12-31): 9.95xDerived (calculated)
- Debt-to-equity (FY 2025-12-31): 0.09xDerived (calculated)
- Capex (YoY) (2025-12-31 vs 2024-12-31): 182.0%Derived (calculated)
- Cash & equivalents (YoY) (2025-12-31 vs 2024-12-31): 43.9%Derived (calculated)
- EPS (basic) (YoY) (2025-12-31 vs 2024-12-31): 126.9%Derived (calculated)
- EPS (diluted) (YoY) (2025-12-31 vs 2024-12-31): 128.0%Derived (calculated)
- Net income (YoY) (2025-12-31 vs 2024-12-31): 129.7%Derived (calculated)
- Operating cash flow (YoY) (2025-12-31 vs 2024-12-31): 62.7%Derived (calculated)
- Operating income (YoY) (2025-12-31 vs 2024-12-31): 145.3%Derived (calculated)
- R&D expense (YoY) (2025-12-31 vs 2024-12-31): 8.3%Derived (calculated)
- Revenue (YoY) (2025-12-31 vs 2024-12-31): 33.9%Derived (calculated)
- Shareholders' equity (YoY) (2025-12-31 vs 2024-12-31): 28.9%Derived (calculated)
- Total assets (YoY) (2025-12-31 vs 2024-12-31): 26.3%Derived (calculated)
- Total liabilities (YoY) (2025-12-31 vs 2024-12-31): 4.4%Derived (calculated)
- Cash & equivalents (annual): USD 496.3MSEC XBRL filing
- Total liabilities (annual): USD 114.23MSEC XBRL filing
- Operating income (annual): USD 161.29MSEC XBRL filing
- Revenue (annual): USD 389.13MSEC XBRL filing
- R&D expense (annual): USD 58.05MSEC XBRL filing
- Capex (annual): USD 11.95MSEC XBRL filing
- Total operating expenses (annual): USD 227.84MSEC XBRL filing