Pliant Therapeutics Inc
Pliant Therapeutics Inc is a biopharmaceutical company focused on the discovery, development, and commercialization of therapeutics targeting the Transforming Growth Factor-beta (TGFβ) pathway for the treatment of fibrotic and inflammatory diseases.
Business. Pliant Therapeutics Inc (PLRX.O) is a pharmaceutical company operating within the Healthcare sector, specifically focused on pharmaceuticals and medical research. The firm is headquartered in the United States and is primarily listed on the NASDAQ stock exchange. As segment and geographic breakdowns are not disclosed, the company is described at the industry level as a participant in the pharmaceutical product-sale market.
Analyst recommendations
6 analysts · consensus HoldAt a glance
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- Company
- EarningsQ3 2026 earnings (expected)2026-10-28 · estimated
- Macro
- Rate decisionBank of England rate decision (press conf.)2026-08-06 · GB
- Rate decisionReserve Bank of Australia rate decision (press conf.)2026-08-12 · AU
- Rate decisionNorges Bank rate decision (press conf.)2026-08-20 · NO
- Rate decisionSveriges Riksbank rate decision (press conf.)2026-09-03 · SE
- Rate decisionBank of Canada rate decision (press conf.)2026-09-09 · CA
- Rate decisionEuropean Central Bank rate decision (press conf.)2026-09-10 · EU
- Macro & political
- ElectionSE Swedish Election2026-09-14 · SE
- ElectionUS U.S. Midterms2026-11-03 · US
- ElectionFR French Legislative2027-06-01 · FR
Pre-earnings brief
Signals & dispatch
Composite-score breakdown
Synthesis
Pliant Therapeutics Inc (PLRX.O) is a pharmaceutical company operating within the Healthcare sector, specifically focused on pharmaceuticals and medical research. The firm is headquartered in the United States and is primarily listed on the NASDAQ stock exchange. As segment and geographic breakdowns are not disclosed, the company is described at the industry level as a participant in the pharmaceutical product-sale market.
Pliant Therapeutics Inc has a market capitalization of $72.13 million and a price-to-book ratio of 0.16, indicating a significant discount to its book value. The company's liquidity position is strong, with a current ratio of 16.12 and $114.297 million in cash and equivalents, which is a substantial buffer against its $84.273 million in total liabilities. The debt-to-equity ratio of 0.07 suggests a conservative capital structure with minimal leverage.
The company's profitability metrics are negative, with a return on equity of -10.74% and a return on assets of -9.00%, reflecting ongoing losses. Operating income for the period was -$52.392 million, and net income was -$46.955 million. These figures indicate that the company is not yet generating positive returns for shareholders and is in a development phase typical of biopharmaceutical firms.
Pliant Therapeutics Inc does not disclose specific revenue segments or geographic breakdowns in the provided data, making it difficult to assess revenue concentration or geographic exposure. However, the company's focus on the TGFβ pathway suggests a specialized therapeutic approach, which may limit its market reach but also reduce direct competition.
The company's growth trajectory is uncertain, with no revenue reported in the latest financial snapshot. Analysts have provided a mean price target of $2.67 and a median price target of $3.00, suggesting a potential upside from the current market price of $1.165. However, the mean recommendation of 3.00 (on a scale from 1 to 5) indicates a neutral outlook, with no strong buy ratings and only one buy rating among the analysts surveyed.
The risk assessment for Pliant Therapeutics Inc indicates low liquidity and dilution risks, with no immediate filing-based flags detected. The company's capital expenditures were -$1.492 million, and its free cash flow was -$47.934 million, reflecting ongoing investment in operations and development. The risk of dilution is currently low, but the company may need to raise additional capital in the future to fund its operations, which could lead to share dilution.
Recent events and filings do not provide specific details on new product launches or regulatory approvals. The company's focus on the TGFβ pathway and its pipeline of therapeutics for fibrotic and inflammatory diseases suggest that future developments in these areas could significantly impact its financial performance and stock price. Investors should monitor clinical trial results and regulatory decisions for potential catalysts.
- Pliant Therapeutics Inc has a strong liquidity position with $114.297 million in cash and equivalents and a current ratio of 16.12.
- The company is not yet profitable, with a return on equity of -10.74% and a return on assets of -9.00%.
- Analysts have provided a mean price target of $2.67, suggesting potential upside from the current market price of $1.165.
- The company's risk assessment indicates low liquidity and dilution risks, but ongoing losses may necessitate future capital raising.
- Pliant Therapeutics Inc's focus on the TGFβ pathway and its pipeline of therapeutics for fibrotic and inflammatory diseases could be key drivers of future growth.
Bull / Bear case
Generated · model-assistedAnalysts project 145.8% upside to a mean price target of $2.67, significantly above the current market price of $1.09.
The company maintains a strong liquidity position with a current ratio of 12.0, indicating ample short-term assets to cover liabilities.
Operating losses improved by 30.7% year-over-year in FY2026, demonstrating a meaningful reduction in operational cash burn rates.
Free cash flow losses decreased by 30.2% year-over-year in FY2026, suggesting improved capital efficiency in recent operations.
The debt-to-equity ratio of 0.07 ranks above the pharmaceutical cohort median, reflecting a conservative capital structure.
The company faces high credit risk, signaling potential difficulties in meeting financial obligations or securing favorable financing terms.
Revenue collapsed to zero in FY2025 and FY2026, highlighting a complete lack of commercial product sales or recurring income.
Net losses widened to $210.3 million in FY2025, reflecting significant ongoing operational deficits despite recent improvement trends.
Cash conversion efficiency of 0.64 is below the pharmaceutical cohort median of 0.95, indicating weaker cash generation capabilities.
In focus — financials by report
Operating income +52,4% YoY; Net income +52,6% YoY.
- ▍Operating income +52,4% YoY
- ▍Net income +52,6% YoY
- ▍Free cash flow +53,2% YoY
Operating income +54,4% YoY; Net income +54,5% YoY.
- ▍Operating income +54,4% YoY
- ▍Net income +54,5% YoY
- ▍Free cash flow +55,5% YoY
Revenue $0.00; Operating income +24,8% YoY.
- ▍Revenue $0.00
- ▍Operating income +24,8% YoY
- ▍Net income +22,5% YoY
- ▍Free cash flow +23,9% YoY
Revenue $0.00; Operating income −12,5% YoY.
- ▍Revenue $0.00
- ▍Operating income −12,5% YoY
- ▍Net income −19,6% YoY
- ▍Free cash flow −16,8% YoY
Revenue $0.00; Operating income -$53.3M.
- ▍Revenue $0.00
- ▍Operating income -$53.3M
Revenue $0.00; Operating income -$62.0M.
- ▍Revenue $0.00
- ▍Operating income -$62.0M
Revenue $0.00; Operating income -$60.6M.
- ▍Revenue $0.00
- ▍Operating income -$60.6M
Revenue $0.00; Operating income -$52.4M.
- ▍Revenue $0.00
- ▍Operating income -$52.4M
Revenue $0.00; Operating income +30,7% YoY.
- ▍Revenue $0.00
- ▍Operating income +30,7% YoY
- ▍Net income +29,0% YoY
- ▍Free cash flow +30,2% YoY
Revenue $0.00, −100,0% YoY; Operating income −24,0% YoY.
- ▍Revenue $0.00, −100,0% YoY
- ▍Operating income −24,0% YoY
- ▍Net income −30,4% YoY
- ▍Free cash flow −32,2% YoY
Revenue $1.6M, −83,7% YoY; Operating income −44,8% YoY.
- ▍Revenue $1.6M, −83,7% YoY
- ▍Operating income −44,8% YoY
- ▍Net income −30,8% YoY
- ▍Free cash flow −30,1% YoY
- ▍Net margin -10211.1%
Revenue $9.7M, +27,9% YoY; Operating income −30,4% YoY.
- ▍Revenue $9.7M, +27,9% YoY
- ▍Operating income −30,4% YoY
- ▍Net income −26,8% YoY
- ▍Free cash flow −26,2% YoY
- ▍Net margin -1273.3%
Valuation TTM
Revenue by segment
Business relationships
Supply chain
Peer comparison
Market position
Stress test
Predictor forecast
| Metric | Our forecast | Guidance | Consensus |
|---|---|---|---|
| EPS | —no estimate | —no estimate | -1,51 |
| Revenue | —no estimate | —no estimate | 0 USD |
| Operating income | —no estimate | —no estimate | -98,0M USD |
Options
Short squeeze
Earnings-call key lines
Consensus distribution
sell-side coverageEstimate revisions
consensus EPS · 26-week trendSell-side observations
Themes
ESG
Risk factors
- No immediate filing-based liquidity or dilution flags were detected.
Benchmarks vs cohort
Corporate actions / M&A
FX exposure
Comparable transactions
Derivatives & instruments
Derivative transactions
- Director · Stock Option (Right to Buy) → Common StockAcquired 70 000 @ $1,14grant · 2026-06-11
- Director · Stock Option (Right to Buy) → Common StockAcquired 70 000 @ $1,14grant · 2026-06-11
- Director · Stock Option (Right to Buy) → Common StockAcquired 70 000 @ $1,14grant · 2026-06-11
- Director · Stock Option (Right to Buy) → Common StockAcquired 70 000 @ $1,14grant · 2026-06-11
- Director · Stock Option (Right to Buy) → Common StockAcquired 70 000 @ $1,14grant · 2026-06-11
- Director · Stock Option (Right to Buy) → Common StockAcquired 70 000 @ $1,14grant · 2026-06-11
- Chief Financial Officer · Stock Option (Right to Buy) → Common StockDisposed 124 000 @ $11,86disposition · 2026-04-17
- Chief Financial Officer · Stock Option (Right to Buy) → Common StockAcquired 124 000 @ $1,33grant · 2026-04-17
- Chief Financial Officer · Stock Option (Right to Buy) → Common StockAcquired 74 250 @ $1,33grant · 2026-04-17
- Chief Operating Officer · Stock Option (Right to Buy) → Common StockAcquired 40 000 @ $1,33grant · 2026-04-17
- Chief Operating Officer · Stock Option (Right to Buy) → Common StockDisposed 55 200 @ $11,14disposition · 2026-04-17
- Chief Operating Officer · Stock Option (Right to Buy) → Common StockAcquired 55 200 @ $1,33grant · 2026-04-17
- Chief Financial Officer · Stock Option (Right to Buy) → Common StockDisposed 76 047 @ $2,08disposition · 2026-04-17
- Chief Financial Officer · Stock Option (Right to Buy) → Common StockDisposed 18 198 @ $6,22disposition · 2026-04-17
- Chief Financial Officer · Stock Option (Right to Buy) → Common StockAcquired 76 047 @ $1,33grant · 2026-04-17
- Chief Financial Officer · Stock Option (Right to Buy) → Common StockAcquired 18 198 @ $1,33grant · 2026-04-17
- Chief Financial Officer · Stock Option (Right to Buy) → Common StockDisposed 74 250 @ $26,50disposition · 2026-04-17
- Chief Operating Officer · Stock Option (Right to Buy) → Common StockDisposed 150 000 @ $16,18disposition · 2026-04-17
- Chief Operating Officer · Stock Option (Right to Buy) → Common StockAcquired 150 000 @ $1,33grant · 2026-04-17
- Chief Operating Officer · Stock Option (Right to Buy) → Common StockDisposed 40 000 @ $17,44disposition · 2026-04-17
- Director, President and CEO · Stock Option (Right to Buy) → Common StockAcquired 250 000 @ $1,33grant · 2026-04-17
- Chief Human Resource Officer · Stock Option (Right to Buy) → Common StockAcquired 51 750 @ $1,33grant · 2026-04-17
- Chief Human Resource Officer · Stock Option (Right to Buy) → Common StockDisposed 51 750 @ $11,14disposition · 2026-04-17
- Chief Human Resource Officer · Stock Option (Right to Buy) → Common StockAcquired 52 000 @ $1,33grant · 2026-04-17
- Chief Human Resource Officer · Stock Option (Right to Buy) → Common StockDisposed 52 000 @ $17,44disposition · 2026-04-17
Actions
Ask Handelsavisen
- Market data
- Market data cache
- Issuer disclosures
- Public news
- Earnings transcripts
- Consensus estimates
- ESG data
- Return On Equitynet_income / total_equity
- Price To Bookmarket_price / (adjusted_book_value / shares_outstanding_diluted)
- Dilution Ratio(shares_outstanding_diluted - shares_outstanding_basic) / shares_outstanding_basic
- Market Priceinput from market-data provider (delayed close or quote-shim mid)
- Market Capmarket_price * shares_outstanding_diluted
- Net Cashcash_and_equivalents + short_term_investments - short_term_debt - long_term_debt
- Pliant Therapeutics Inc Market data — financials · 2026-05-29
- Pliant Therapeutics Inc Market data — analyst estimates · 2026-05-29
- Pliant Therapeutics Inc Market data — ESG · 2026-05-29
Ownership & reference
Top holders
- Investment Managers · as of 2024-06-300,00 %$53M
- Investment Managers · as of 2024-12-310,00 %$3M
- Investment Managers · as of 2026-03-310,00 %$1M
- Investment Managers · as of 2026-03-310,00 %$1M
- Investment Managers · as of 2025-12-310,00 %$3M
- Investment Managers · as of 2026-03-310,00 %$1M
- Investment Managers · as of 2026-03-310,00 %$1M
- Investment Managers · as of 2026-03-310,00 %$0M
- Investment Managers · as of 2026-03-310,00 %$0M
- Funds · as of 2026-03-310,00 %$0M
- Institutional Investor · as of 2026-03-310,00 %$0M
- Investment Managers · as of 2026-03-310,00 %$0M
- Institutional Investor · as of 2026-03-310,00 %$0M
- Institutional Investor · as of 2026-03-310,00 %$0M
- Brokerage Firms · as of 2026-03-310,00 %$0M
Insider activity
- Chief Financial Officer · Common StockSold 24 002 @ $1,28$31K · 2026-01-20
- Chief Human Resource Officer · Common StockSold 7 534 @ $1,28$10K · 2026-01-20
- Director, President and CEO · Common StockSold 89 375 @ $1,28$114K · 2026-01-20
- Chief Operating Officer · Common StockSold 6 917 @ $1,28$9K · 2026-01-20
Short positioning
Geographic breakdown
Intel & risk
Evidence & claims
From filings & derived data- Capex (YoY) (2025-12-31 vs 2024-12-31): -90.3%Derived (calculated)
- Total liabilities (YoY) (2025-12-31 vs 2024-12-31): -52.6%Derived (calculated)
- Total assets (YoY) (2025-12-31 vs 2024-12-31): -43.3%Derived (calculated)
- Shareholders' equity (YoY) (2025-12-31 vs 2024-12-31): -40.4%Derived (calculated)
- Return on equity (FY 2025-12-31): 82.4%Derived (calculated)
- Return on assets (FY 2025-12-31): 66.3%Derived (calculated)
- Current ratio (FY 2025-12-31): 12.00xDerived (calculated)
- Debt-to-equity (FY 2025-12-31): 0.24xDerived (calculated)
- EPS (diluted) (YoY) (2025-12-31 vs 2024-12-31): 30.0%Derived (calculated)
- R&D expense (YoY) (2025-12-31 vs 2024-12-31): -35.5%Derived (calculated)
- Operating income (YoY) (2025-12-31 vs 2024-12-31): 31.5%Derived (calculated)
- Operating cash flow (YoY) (2025-12-31 vs 2024-12-31): 17.5%Derived (calculated)
- Net income (YoY) (2025-12-31 vs 2024-12-31): -29.0%Derived (calculated)
- Long-term debt (YoY) (2025-12-31 vs 2024-12-31): -100.0%Derived (calculated)
- Cash & equivalents (YoY) (2025-12-31 vs 2024-12-31): -36.2%Derived (calculated)
- EPS (basic) (YoY) (2025-12-31 vs 2024-12-31): 30.0%Derived (calculated)
- Long-term debt (annual): USD 0SEC XBRL filing
- Shares outstanding (annual): 61.45MSEC XBRL filing
- Total liabilities (annual): USD 44.02MSEC XBRL filing
- Current liabilities (annual): USD 16.36MSEC XBRL filing
- Current assets (annual): USD 196.45MSEC XBRL filing
- Revenue (annual): USD 0SEC XBRL filing
- Net income (annual): USD 149.3MSEC XBRL filing
- Total operating expenses (annual): USD 156.37MSEC XBRL filing