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PMN.O NASDAQ Biotechnology & Medical Research

ProMIS Neurosciences Inc

$14,42
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Mcap
129,3M USD
P/E
EV / Rev
Div yield
Op margin
ROE
-4 714,8 %
Net margin
Debt / equity
0,00
Beta
52w range
Volume
Day range
$10,50–$10,96
Prev close
$10,87
Open
$10,44
Next earnings
2026-10-28
Ex-dividend
TR 1Y
About

ProMIS Neurosciences Inc is a clinical-stage biopharmaceutical company focused on the discovery and development of novel therapeutics for neurodegenerative diseases, primarily Alzheimer's disease.

Business. ProMIS Neurosciences Inc (PMN.O) is a biotechnology and medical research company operating within the healthcare sector. The firm is headquartered in the United States and is primarily listed on the NASDAQ stock exchange. Specific details regarding operating segments and geographic revenue mix are not available.

Classification92 %
SectorHealthcare
Business sectorPharmaceuticals & Medical Research
IndustryBiotechnology & Medical Research
ActivityPharmaceuticals & Medical Research
Generated · model-assisted
Sell-side consensus
BUY4 analysts
4 buy0 hold0 sell
Avg 12m price target34,38

Analyst recommendations

4 analysts · consensus Buy
Buy4
Hold0
Sell0
12-month price target
34,38
Consensus of sell-side coverage.
Upcoming events
  • EarningsQ3 2026 earnings (expected)2026-10-28 · estimated
See all catalysts →

At a glance

Score
not yet scored
Valuation
valuation pending
Analysts
Buy
4 analysts · indicative
Ownership
JANUS HENDERSON GROUP PLC
largest disclosed fund holder
Profitability
-4 714,8 %
return on equity
Quality
not yet scored

What drives this business

The watch-list the newsroom runs for this company — derived from its sector path, sharpened layer by layer. Not investment advice.

— missing data

News & coverage

0
  • No recent newsroom coverage mentioning PMN.
  • Sector rotation

    Sector1D1Mvs mkt
    Materials+2,3 %+6,6 %+1,7 %
    Communication Services+2,2 %−5,5 %+1,6 %
    Energy+0,6 %+3,3 %+0,0 %
    Health Care · THIS SECTOR+0,6 %−0,8 %+0,0 %
    Information Technology+0,6 %+6,7 %+0,0 %
    Consumer Discretionary+0,4 %+7,6 %−0,2 %
    Financials−0,3 %−2,8 %−0,9 %
    Consumer Staples−0,4 %+2,5 %−1,0 %
    Real Estate−0,7 %+10,9 %−1,3 %
    Industrials−1,9 %−3,1 %−2,5 %
    Utilities−1,9 %+28,2 %−2,5 %

    Developing storylines

    No tracked sagas currently linked to PMN.O. Browse all sagas →

    Analysis

    AI analysis
    Generated · analysis pipeline · tier hybrid · as of 2026-08-04 ↑ At a glance

    Opportunity

    — missing data

    Upcoming catalysts

    Scheduled public events. Informational only — not investment advice.

    • Company
    • EarningsQ3 2026 earnings (expected)2026-10-28 · estimated
    • Macro
    • Rate decisionBank of England rate decision (press conf.)2026-08-06 · GB
    • Rate decisionReserve Bank of Australia rate decision (press conf.)2026-08-12 · AU
    • Rate decisionNorges Bank rate decision (press conf.)2026-08-20 · NO
    • Rate decisionSveriges Riksbank rate decision (press conf.)2026-09-03 · SE
    • Rate decisionBank of Canada rate decision (press conf.)2026-09-09 · CA
    • Rate decisionEuropean Central Bank rate decision (press conf.)2026-09-10 · EU
    • Macro & political
    • ElectionSE Swedish Election2026-09-14 · SE
    • ElectionUS U.S. Midterms2026-11-03 · US
    • ElectionFR French Legislative2027-06-01 · FR

    Pre-earnings brief

    — missing data

    Signals & dispatch

    peak dispatch · —

    Composite-score breakdown

    Synthesis

    Business

    ProMIS Neurosciences Inc (PMN.O) is a biotechnology and medical research company operating within the healthcare sector. The firm is headquartered in the United States and is primarily listed on the NASDAQ stock exchange. Specific details regarding operating segments and geographic revenue mix are not available.

    Classification92 %
    SectorHealthcare
    Business sectorPharmaceuticals & Medical Research
    IndustryBiotechnology & Medical Research
    ActivityPharmaceuticals & Medical Research
    AI synthesis
    GENERATED

    ProMIS Neurosciences Inc operates with a highly leveraged equity structure, as evidenced by a price-to-book ratio of 1230.59 and a price-to-tangible-book ratio of 1230.59, indicating that the market capitalization significantly exceeds the book value of the company's tangible assets. The company has no long-term debt, and its debt-to-equity ratio is 0.0, suggesting a purely equity-funded capital structure. However, the company's liquidity position is rated as low, with a current ratio of 1.34, indicating that it has just enough current assets to cover its current liabilities.

    The company's profitability is negative, with a return on equity of -47.15% and a return on assets of -1.02%, both of which are significantly below the industry median for biotechnology firms. The company reported a net loss of $3.64 million and an operating loss of $3.68 million in the latest period. These figures suggest that the company is not currently generating positive returns for its shareholders and is operating at a loss.

    Geographically and segment-wise, the company's revenue concentration is not disclosed in the available data. However, as a clinical-stage biopharmaceutical company, its operations are likely concentrated in the United States, where the majority of its research and development activities are conducted. The company's business is heavily dependent on the success of its clinical trials and the eventual commercialization of its drug candidates.

    The company's growth trajectory is speculative, as it is in the clinical development phase and has not yet commercialized any products. The outlook for the current fiscal year is not provided, but the company's operating cash flow of -$10.29 million and free cash flow of -$3.64 million indicate that it is not generating positive cash flows from operations. The company will need to secure additional financing to fund its operations and clinical trials, which could lead to further dilution of existing shareholders.

    The risk assessment for the company indicates a low probability of immediate liquidity or dilution risks. However, the company's reliance on equity financing and the absence of long-term debt suggest that it may face dilution pressures in the future if it needs to raise additional capital to fund its operations. The company's dilution potential is currently rated as low, but this could change if the company's cash burn rate increases or if it fails to secure additional funding.

    Recent events and filings do not indicate any immediate financial or operational risks for the company. The company has not issued any recent press releases or filed any 10-K or 10-Q reports that would suggest a material change in its financial condition or business strategy. However, the company's reliance on clinical trial outcomes and the regulatory approval process for its drug candidates introduces a high degree of uncertainty into its future prospects.

    Key takeaways
    • ProMIS Neurosciences Inc is a clinical-stage biopharmaceutical company with no long-term debt and a highly leveraged equity structure.
    • The company is currently operating at a loss, with a return on equity of -47.15% and a return on assets of -1.02%.
    • The company's liquidity position is rated as low, with a current ratio of 1.34, indicating that it has just enough current assets to cover its current liabilities.
    • The company's growth trajectory is speculative, as it is in the clinical development phase and has not yet commercialized any products.
    • The company's risk assessment indicates a low probability of immediate liquidity or dilution risks, but its reliance on equity financing could lead to future dilution pressures.

    Bull / Bear case

    Generated · model-assisted
    — missing data

    In focus — financials by report

    Quarterly
    Annual
    QUARTERLYFiled 2025-11-12
    Q3 2025 · Quarter highlights
    Open report →

    Operating income −165,0% YoY; Net income −224,8% YoY.

    Revenue
    Operating income-$11.8M−165,0 % YoY
    Net income-$11.6M−224,8 % YoY
    Free cash flow
    EPS
    Operating cash flow-$18.8M−2,0 % YoY
    Financials
    Income statement
    Revenue
    Gross profit
    Operating income-$11.8M
    Net income-$11.6M
    Balance sheet
    Total assets$21.5M
    Total liabilities$12.3M
    Total equity$9.2M
    Cash & equivalents
    Long-term debt$0.00
    Cash flow
    Operating cash flow-$18.8M
    CapEx
    Free cash flow
    SBC
    Highlights
    • Operating income −165,0% YoY
    • Net income −224,8% YoY

    Valuation TTM

    Market price
    $14,42
    Market cap
    $94.9M
    Enterprise value
    P/E
    Non-GAAP P/E
    EV / Revenue
    EV / Op income
    EV / OCF
    P / B
    1230.6x
    P / Tangible book
    1230.6x
    Tangible book
    $77.1k
    Net cash
    Current ratio
    1.3
    Debt / equity
    0.0
    ROA
    -1.0%
    ROE
    -47.1%
    Cash conversion
    283.0%
    CapEx / revenue
    SBC / revenue
    Dilution ratio
    0.0%

    Revenue by segment

    Market share

    — missing data

    Business relationships

    Business relationships1 disclosed relationship · 1 type · extracted from filings & disclosures
    Subsidiaries1
    EX21:74fa3ac8cc41EX21:74fa3ac8cc41Subsidiarie97%

    Supply chain

    — missing data

    Peer comparison

    — missing data

    Market position

    Stress test

    — missing data

    Predictor forecast

    Next quarternear-term
    Earnings · next quarterconf 45 %
    EPS
    Consensus EPS
    -5,05
    Predicted surprise
    +0,00
    Beat probability
    45 %
    Analysts
    4
    Other metrics
    Revenue
    no estimate
    Segment revenue
    no estimate
    Margin
    no estimate
    Segment margin
    no estimate
    as of 2026-05-16 · Earnings Surprise V1
    Period note: consensus is not fiscal-period-aligned at source — read as consensus vs the last reported actual, not a calibrated same-quarter surprise.
    Full fiscal year~1 year ahead
    Full fiscal year · our forecast vs guidance vs consensus
    MetricOur forecastGuidanceConsensus
    EPSno estimateno estimate-5,05
    Revenueno estimateno estimate0 USD
    Operating incomeno estimateno estimate-46,0M USD
    Full-year consensus mean (period as reported by source) · consensus in USD. Company-level full-year forecast and management guidance are not yet modelled at scale — shown as "no estimate", never inferred.
    Probabilistic model output — not investment advice. · generated 2026-08-04

    Options

    — missing data

    Short squeeze

    — missing data

    Earnings-call key lines

    — missing data

    Consensus distribution

    sell-side coverage
    Recommendation distribution4 analysts
    Strong buy1
    Buy3
    Hold0
    Sell0
    Strong sell0
    12-month price target$34,38 · Median $35,00
    Low $18,00High $49,50
    Operating income · consensus-46,0M USD
    EPS surprise
    −348,0 %
    reported vs consensus · miss

    Estimate revisions

    consensus EPS · 26-week trend
    — missing data

    Sell-side observations

    Low$18,00
    Mean$34,38
    Median$35,00
    High$49,50
    Spot$14,42
    +138.4 %implied to mean12-month sell-side price targets · ▲ spot

    Themes

    — missing data

    ESG

    — missing data

    Risk factors

    Dilution riskLow
    Liquidity riskLow
    Filing-based flags
    • No immediate filing-based liquidity or dilution flags were detected.

    Benchmarks vs cohort

    ROE-4 714,8 %Bottom quartile
    D/E0,00Above median
    Cash Conv2,83Best in class

    Corporate actions / M&A

    — missing data

    FX exposure

    — missing data

    Comparable transactions

    — missing data

    Derivatives & instruments

    Derivative transactions

    Net acquired 1 123 418 sh20 grants11 insiders
    • WYMAN WILLIAM WDirector · Option (right to buy) → Common SharesAcquired 11 000 @ $10,77grant · 2026-05-20
    • WYMAN WILLIAM WDirector · Option (right to buy) → Common SharesAcquired 5 500 @ $10,77grant · 2026-05-20
    • Williams EugeneDirector · Option (right to buy) → Common SharesAcquired 5 500 @ $10,77grant · 2026-05-20
    • Williams EugeneDirector · Option (right to buy) → Common SharesAcquired 11 000 @ $10,77grant · 2026-05-20
    • Warma Neil KDirector, Chief Executive Officer · Option (right to buy) → Common SharesAcquired 160 000 @ $10,77grant · 2026-05-20
    • Mandel-Brehm JoshDirector · Option (right to buy) → Common SharesAcquired 5 500 @ $10,77grant · 2026-05-20
    • Shafmaster Madge K.Director · Option (right to buy) → Common SharesAcquired 5 500 @ $10,77grant · 2026-05-20
    • Shafmaster Madge K.Director · Option (right to buy) → Common SharesAcquired 11 000 @ $10,77grant · 2026-05-20
    • Cashman NeilDirector, Chief Scientific Officer · Option (right to buy) → Common SharesAcquired 50 000 @ $10,77grant · 2026-05-20
    • Alex Slanix PaulDirector · Option (right to buy) → Common SharesAcquired 11 000 @ $10,77grant · 2026-05-20
    • Alex Slanix PaulDirector · Option (right to buy) → Common SharesAcquired 5 500 @ $10,77grant · 2026-05-20
    • Kaplan JohanneChief Development Officer · Option (right to buy) → Common SharesAcquired 50 000 @ $10,77grant · 2026-05-20
    • Mandel-Brehm JoshDirector · Option (right to buy) → Common SharesAcquired 11 000 @ $10,77grant · 2026-05-20
    • Milbury Max A.Principal Accounting Officer · Option (right to buy) → Common SharesAcquired 18 167 @ $10,77grant · 2026-05-20
    • Cashman NeilDirector, Chief Scientific Officer · Warrants to purchase Common Shares → Common SharesAcquired 4 122 @ $14,40grant · 2026-02-03
    • ABG Management Ltd.10% owner · Warrants → Common SharesAcquired 700 741 @ $14,40purchase · 2026-02-03
    • Kirwin Patrick D.Director · Warrants to purchase Common Shares → Common SharesAcquired 3 050 @ $14,40grant · 2026-02-03
    • Milbury Max A.Principal Accounting Officer · Warrants to purchase Common Shares → Common SharesAcquired 6 595 @ $14,40grant · 2026-02-03
    • Warma Neil KDirector, Chief Executive Officer · Warrants to purchase Common Shares → Common SharesAcquired 6 183 @ $14,40grant · 2026-02-03
    • Kaplan JohanneChief Development Officer · Warrants to purchase Common Shares → Common SharesAcquired 2 060 @ $14,40grant · 2026-02-03
    • ABG Management Ltd.10% owner · Option (right to buy) → Common SharesAcquired 40 000 @ $0,45grant · 2025-10-22

    Actions

    Ask Handelsavisen

    — missing data
    Data sources
    • Market data
    • Market data cache
    • Issuer disclosures
    • Public news
    • Earnings transcripts
    • Consensus estimates
    • ESG data
    How metrics are computed
    • Dilution Ratio
      (shares_outstanding_diluted - shares_outstanding_basic) / shares_outstanding_basic
    • Market Price
      input from market-data provider (delayed close or quote-shim mid)
    • Market Cap
      market_price * shares_outstanding_diluted
    • Return On Equity
      net_income / total_equity
    • Price To Tangible Book
      market_price / (tangible_book_value / shares_outstanding_diluted)
    • Debt To Equity
      (short_term_debt + long_term_debt) / total_equity
    Source documents
    • ProMIS Neurosciences Inc Market data — financials · 2026-05-29
    • ProMIS Neurosciences Inc Market data — analyst estimates · 2026-05-29

    Ownership & reference

    Top holders

    • JANUS HENDERSON GROUP PLCInstitutional Investor · as of 2026-03-310,01 %$16M
    • Wellington Management Company, LLPInvestment Managers · as of 2026-03-310,00 %$9M
    • UBS Financial Services, Inc.Investment Managers · as of 2026-03-310,00 %$0M

    Leadership

    • Eugene WilliamsExecutive Chairman of the Board

    Insider activity

    Net buying8 buys · 0 sellsnet $8,7M7 insiders · last 365d
    • Kirwin Patrick D.Director · Common SharesBought 4 000 @ $11,33$45K · 2026-04-22
    • Williams EugeneDirector · Common SharesBought 2 000 @ $24,40$49K · 2026-03-05
    • Williams EugeneDirector · Common SharesBought 2 000 @ $24,00$48K · 2026-03-04
    • Williams EugeneDirector · Common SharesBought 1 000 @ $21,89$22K · 2026-03-03
    • Williams EugeneDirector · Common SharesBought 1 000 @ $22,53$23K · 2026-03-02
    • Kaplan JohanneChief Development Officer · Common SharesBought 1 629 @ $15,35$25K · 2026-02-19
    • Kaplan JohanneChief Development Officer · Common SharesOther 2 060 @ $12,13$25K · 2026-02-03
    • Cashman NeilDirector, Chief Scientific Officer · Common SharesOther 4 122 @ $12,13$50K · 2026-02-03
    • Warma Neil KDirector, Chief Executive Officer · Common SharesOther 6 183 @ $12,13$75K · 2026-02-03
    • Milbury Max A.Principal Accounting Officer · Common SharesOther 6 595 @ $12,13$80K · 2026-02-03
    • Kirwin Patrick D.Director · Common SharesOther 3 050 @ $12,13$37K · 2026-02-03
    • ABG Management Ltd.10% owner · Common SharesBought 700 741 @ $12,13$8,5M · 2026-02-03
    • Milbury Max A.Principal Accounting Officer · Common SharesBought 30 392 @ $0,49$15K · 2025-10-03

    Short positioning

    235.8Kshares short+15.6% vs prior
    3.13days to cover
    47.8%short of daily vol
    6.6Kfails-to-deliver
    as of 2026-07-15 · short-interest report (free)

    Geographic breakdown

    — missing data
    Listings · one canonical issuer all listings resolve to the canonical
    PMN.OCanonical
    NASDAQ · USD

    Intel & risk

    PredictorBeat prob45 %Surprise+0,00Full forecast →
    peak dispatch · —
    OSINT findings
    Dilution riskLow
    Liquidity riskLow
    No immediate filing-based liquidity or dilution flags were detected.
    Relationship graph
    PMNEX21:74fBiotechnology
    This companySectorSubsidiaries

    Evidence & claims

    From filings & derived data
    • Total assets (YoY) (2025-12-31 vs 2024-12-31): -51.4%Derived (calculated)
    • Shareholders' equity (YoY) (2025-12-31 vs 2024-12-31): -107.6%Derived (calculated)
    • R&D expense (YoY) (2025-12-31 vs 2024-12-31): 213.8%Derived (calculated)
    • Operating income (YoY) (2025-12-31 vs 2024-12-31): -138.7%Derived (calculated)
    • Operating cash flow (YoY) (2025-12-31 vs 2024-12-31): -3.4%Derived (calculated)
    • Net income (YoY) (2025-12-31 vs 2024-12-31): -1,529.3%Derived (calculated)
    • EPS (diluted) (YoY) (2025-12-31 vs 2024-12-31): -959.7%Derived (calculated)
    • Return on equity (FY 2025-12-31): 3,155.8%Derived (calculated)
    • Return on assets (FY 2025-12-31): -432.6%Derived (calculated)
    • Debt-to-equity (FY 2025-12-31): -8.30xDerived (calculated)
    • EPS (basic) (YoY) (2025-12-31 vs 2024-12-31): -943.7%Derived (calculated)
    • Cash & equivalents (YoY) (2025-12-31 vs 2024-12-31): -54.0%Derived (calculated)
    • Current ratio (FY 2025-12-31): 0.88xDerived (calculated)
    • Total liabilities (YoY) (2025-12-31 vs 2024-12-31): 330.9%Derived (calculated)
    • Current assets (annual): USD 9.18MSEC XBRL filing
    • Shares outstanding (annual): 2.15MSEC XBRL filing
    • EPS (basic) (annual): USD-PER-SHARES -23SEC XBRL filing
    • Total operating expenses (annual): USD 40.17MSEC XBRL filing
    • Net income (annual): USD -39.72MSEC XBRL filing
    • Cash & equivalents (annual): USD 6.12MSEC XBRL filing
    • Shareholders' equity (annual): USD -1.26MSEC XBRL filing
    • Operating cash flow (annual): USD -28.12MSEC XBRL filing
    • Total assets (annual): USD 9.18MSEC XBRL filing
    • Total liabilities (annual): USD 10.44MSEC XBRL filing
    Showing 24 of 60 surfaced claims.
    Atomic claims from regulatory filings and derived calculations. Provenance shown as source kind only.

    The Thread

    Everything we know, in order
    2026-10-28EVENTUpcomingQ3 2026 earnings (expected) estimated date
    2026-06-30 03:38 UTCEARNINGSUpcomingForecast: earnings_forecast (90d)
    2026-05-20 00:00 UTCINSIDER14 insider transactions — 2026-05 14 derivative
    2026-05-20FILING8-K filing →
    2026-05-20INSIDERWYMAN WILLIAM W acquired 5.5k sh Option (right to buy) — Director
    2026-05-20INSIDERWilliams Eugene acquired 11.0k sh Option (right to buy) — Director
    2026-05-20INSIDERWarma Neil K acquired 160.0k sh Option (right to buy) — Director, Chief Executive Officer
    2026-05-20INSIDERWilliams Eugene acquired 5.5k sh Option (right to buy) — Director
    2026-05-20INSIDERWYMAN WILLIAM W acquired 11.0k sh Option (right to buy) — Director
    2026-05-20INSIDERMandel-Brehm Josh acquired 5.5k sh Option (right to buy) — Director
    2026-05-20INSIDERKaplan Johanne acquired 50.0k sh Option (right to buy) — Chief Development Officer
    2026-05-20INSIDERAlex Slanix Paul acquired 5.5k sh Option (right to buy) — Director
    2026-05-20INSIDERShafmaster Madge K. acquired 5.5k sh Option (right to buy) — Director
    2026-05-20INSIDERShafmaster Madge K. acquired 11.0k sh Option (right to buy) — Director
    2026-05-20INSIDERCashman Neil acquired 50.0k sh Option (right to buy) — Director, Chief Scientific Officer
    2026-05-20INSIDERMilbury Max A. acquired 18.2k sh Option (right to buy) — Principal Accounting Officer
    2026-05-20INSIDERAlex Slanix Paul acquired 11.0k sh Option (right to buy) — Director
    2026-05-20INSIDERMandel-Brehm Josh acquired 11.0k sh Option (right to buy) — Director
    2026-05-12FILING10-Q filing →
    2026-05-12FILING8-K filing →
    2026-04-22 00:00 UTCINSIDER1 insider transaction — 2026-04
    2026-04-22INSIDERKirwin Patrick D. bought 4.0k sh Common Shares — Director ~$45k
    2026-04-09FILINGDEF 14A filing →
    2026-03-25FILING10-K filing →
    2026-03-25FILING8-K filing →
    2026-03-05 00:00 UTCINSIDER4 insider transactions — 2026-03 · net buy $141k
    2026-03-05INSIDERWilliams Eugene bought 2.0k sh Common Shares — Director ~$49k
    2026-03-04INSIDERWilliams Eugene bought 2.0k sh Common Shares — Director ~$48k
    2026-03-03INSIDERWilliams Eugene bought 1.0k sh Common Shares — Director ~$22k
    2026-03-02INSIDERWilliams Eugene bought 1.0k sh Common Shares — Director ~$23k
    2026-02-19 00:00 UTCINSIDER13 insider transactions — 2026-02 · net buy $8.8M 6 derivative
    2026-02-19INSIDERKaplan Johanne bought 1.6k sh Common Shares — Chief Development Officer ~$25k
    2026-02-03INSIDERKaplan Johanne transacted 2.1k sh Common Shares — Chief Development Officer ~$25k
    2026-02-03INSIDERCashman Neil transacted 4.1k sh Common Shares — Director, Chief Scientific Officer ~$50k
    2026-02-03INSIDERWarma Neil K transacted 6.2k sh Common Shares — Director, Chief Executive Officer ~$75k
    2026-02-03INSIDERMilbury Max A. transacted 6.6k sh Common Shares — Principal Accounting Officer ~$80k
    2026-02-03INSIDERKirwin Patrick D. transacted 3.0k sh Common Shares — Director ~$37k
    2026-02-03INSIDERABG Management Ltd. bought 700.7k sh Common Shares — 10% owner ~$8.50M
    2026-02-03INSIDERWarma Neil K acquired 6.2k sh Warrants to purchase Common Shares — Director, Chief Executive Officer
    2026-02-03INSIDERCashman Neil acquired 4.1k sh Warrants to purchase Common Shares — Director, Chief Scientific Officer
    Showing the 40 most recent of 63 entries.
    The entity's full life in the product — typed, chronological, joined across Newspaper, Platform and Data. Our memory, made visible.
    Sources filings · IR · transcripts · market data · tier hybrid · as of 2026-08-04 Market data · Issuer disclosures · Public news · Earnings transcripts · Consensus estimates · ESG data Premium coverage