Spero Therapeutics Inc

Spero Therapeutics maintains a strong liquidity position with $63.5 million in cash and equivalents, representing 42.4% of total assets, and a current ratio of 2.68, indicating the company can cover its short-term obligations comfortably. The company has no long-term debt, and its debt-to-equity ratio is 0.0, suggesting a conservative capital structure with no leverage risk. However, the company reported negative operating cash flow of $12.8 million and free cash flow of $17.9 million, reflecting ongoing operational cash burn.

Profitability metrics show significant underperformance relative to industry norms. The company reported a net loss of $17.9 million and an operating loss of $19.1 million, with a return on equity (ROE) of -22.2% and return on assets (ROA) of -11.9%. These figures indicate that Spero is not generating returns for shareholders or asset holders and is likely in a pre-revenue or early-stage development phase. The price-to-book ratio of 1.99 suggests the market is valuing the company at a premium to its tangible book value, potentially reflecting expectations of future growth or asset value realization.

Spero Therapeutics does not disclose segment or geographic revenue breakdowns in the latest financial data, making it difficult to assess revenue concentration or geographic exposure. The absence of segment data implies the company operates as a single business unit, likely focused on its core pipeline of antibiotics.

The company's growth trajectory is uncertain, with no revenue growth reported in the latest period. The lack of revenue and the continued net losses suggest the company is in a development or clinical trial phase, with no commercialized products yet generating revenue. Analysts have assigned a mean price target of $4.00, implying a potential 44.6% upside from the current market price of $2.76, but the absence of strong-buy or buy ratings suggests limited conviction in the near-term upside.

Risk factors include the company's reliance on external financing to fund operations, as it has no long-term debt and is burning cash. The risk assessment indicates low liquidity and dilution risk, but the absence of long-term debt does not eliminate the need for ongoing capital raises. The company has not issued any dilutive securities in the latest period, and no filing-based dilution flags were detected, suggesting a low near-term dilution risk.

Recent events include the continued development of its lead candidate, SPR720, a novel antibiotic targeting drug-resistant Gram-negative bacteria. The company is preparing for potential regulatory submissions and clinical trials, but no recent filings or transcripts indicate significant progress or setbacks in the pipeline.

Revenue grew 39.2% year-over-year to $66.8 million in FY2026, demonstrating strong top-line expansion momentum.

The company returned to profitability with $8.6 million net income in FY2026, reversing a significant prior-year loss.

Free cash flow turned positive to $8.6 million in FY2026, indicating improved operational cash generation capabilities.

Operating margin of -1.87% outperforms the biotechnology cohort median of -2.56%, suggesting relative efficiency.

The stock trades at $1.38, implying 189.9% upside to the single analyst consensus price target of $4.00.

Cash conversion ratio of 0.72 lags the biotechnology cohort median of 0.87, indicating weaker cash generation quality.

The company carries a medium credit risk flag, highlighting potential vulnerabilities in its financial stability profile.

Institutional ownership is extremely fragmented with top five holders controlling zero percent of the company.

Revenue $0.00, −100,0% YoY.

• ▍Revenue $0.00, −100,0% YoY

Revenue $41.3M, +174,5% YoY; Operating income +244,6% YoY.

• ▍Revenue $41.3M, +174,5% YoY
• ▍Operating income +244,6% YoY
• ▍Net income +250,9% YoY
• ▍Free cash flow +250,9% YoY
• ▍Net margin 76.3%

Revenue $5.4M, −59,6% YoY; Operating income +57,4% YoY.

• ▍Revenue $5.4M, −59,6% YoY
• ▍Operating income +57,4% YoY
• ▍Net income +57,0% YoY
• ▍Free cash flow +57,0% YoY
• ▍Net margin -135.6%

Revenue $14.2M, +39,1% YoY; Operating income +87,2% YoY.

• ▍Revenue $14.2M, +39,1% YoY
• ▍Operating income +87,2% YoY
• ▍Net income +90,5% YoY
• ▍Net margin -12.0%

Revenue $5.9M; Operating income -$14.7M.

• ▍Revenue $5.9M
• ▍Operating income -$14.7M
• ▍Net margin -236.1%

Revenue $15.0M; Operating income -$21.7M.

• ▍Revenue $15.0M
• ▍Operating income -$21.7M
• ▍Net margin -138.8%

Revenue $13.5M; Operating income -$18.6M.

• ▍Revenue $13.5M
• ▍Operating income -$18.6M
• ▍Net margin -127.3%

Revenue $10.2M; Operating income -$19.1M.

• ▍Revenue $10.2M
• ▍Operating income -$19.1M
• ▍Net margin -175.2%

Revenue $66.8M, +39,2% YoY; Operating income +108,6% YoY.

• ▍Revenue $66.8M, +39,2% YoY
• ▍Operating income +108,6% YoY
• ▍Net income +112,5% YoY
• ▍Free cash flow +112,5% YoY
• ▍Net margin 12.8%

Revenue $48.0M, −53,8% YoY; Operating income −441,5% YoY.

• ▍Revenue $48.0M, −53,8% YoY
• ▍Operating income −441,5% YoY
• ▍Net income −400,6% YoY
• ▍Free cash flow −395,5% YoY
• ▍Net margin -142.9%

Revenue $103.8M, +94,0% YoY; Operating income +146,9% YoY.

• ▍Revenue $103.8M, +94,0% YoY
• ▍Operating income +146,9% YoY
• ▍Net income +149,1% YoY
• ▍Free cash flow +150,9% YoY
• ▍Net margin 22.0%

Revenue $53.5M, +193,1% YoY; Operating income +48,0% YoY.

• ▍Revenue $53.5M, +193,1% YoY
• ▍Operating income +48,0% YoY
• ▍Net income +48,3% YoY
• ▍Free cash flow +48,9% YoY
• ▍Net margin -86.7%