Spruce Biosciences, Inc
Spruce Biosciences, Inc develops and commercializes diagnostic tests for the detection of SARS-CoV-2 and other infectious diseases, primarily generating revenue through the sale of its diagnostic kits and related services.
Business. Spruce Biosciences, Inc. (SPRB.O) is a biotechnology and medical research company engaged in healthcare diagnostics. The firm is headquartered in the United States and is primarily listed on the NASDAQ stock exchange. Specific details regarding operating segments and geographic revenue mix are not available.
Analyst recommendations
5 analysts · consensus BuyAt a glance
What drives this business
The watch-list the newsroom runs for this company — derived from its sector path, sharpened layer by layer. Not investment advice.
News & coverage
0Sector rotation
Developing storylines
Analysis
AI analysisOpportunity
Upcoming catalysts
Scheduled public events. Informational only — not investment advice.
- Macro
- Rate decisionBank of England rate decision (press conf.)2026-08-06 · GB
- Rate decisionReserve Bank of Australia rate decision (press conf.)2026-08-12 · AU
- Rate decisionNorges Bank rate decision (press conf.)2026-08-20 · NO
- Rate decisionSveriges Riksbank rate decision (press conf.)2026-09-03 · SE
- Rate decisionBank of Canada rate decision (press conf.)2026-09-09 · CA
- Rate decisionEuropean Central Bank rate decision (press conf.)2026-09-10 · EU
- Macro & political
- ElectionSE Swedish Election2026-09-14 · SE
- ElectionUS U.S. Midterms2026-11-03 · US
- ElectionFR French Legislative2027-06-01 · FR
Pre-earnings brief
Signals & dispatch
Composite-score breakdown
Synthesis
Spruce Biosciences, Inc. (SPRB.O) is a biotechnology and medical research company engaged in healthcare diagnostics. The firm is headquartered in the United States and is primarily listed on the NASDAQ stock exchange. Specific details regarding operating segments and geographic revenue mix are not available.
Spruce Biosciences maintains a strong liquidity position, with $81.15 million in cash and equivalents, significantly exceeding its total liabilities of $20.92 million, resulting in a current ratio of 4.67. The company's price-to-book ratio of 2.39 suggests a premium valuation relative to its book value, while the debt-to-equity ratio of 0.04 indicates minimal leverage.
The company's profitability remains negative, with a net loss of $11.63 million and an operating loss of $12.63 million in the latest reporting period. Return on equity (ROE) and return on assets (ROA) are -17.45% and -13.28%, respectively, indicating poor capital efficiency and asset utilization. These metrics fall below the typical performance benchmarks for the biotechnology and medical research industry, where positive returns are often necessary to justify high valuations.
Spruce Biosciences derives its revenue primarily from the sale of diagnostic tests, with a geographic focus on the United States. The company's revenue concentration is not disclosed in the available data, but its operations are likely subject to regulatory and market dynamics in the U.S. healthcare sector.
The company's growth trajectory is uncertain, with no specific revenue growth projections provided in the available data. However, the high price targets from analysts, ranging from $140 to $283 per share, suggest optimism about the company's long-term potential. The mean price target of $186.60 implies a significant upside from the current market price of $59.
Risk factors for Spruce Biosciences include the volatility of the biotechnology sector, regulatory changes affecting diagnostic testing, and the potential for dilution if the company raises additional capital. The risk assessment indicates low liquidity and dilution risk, with no immediate filing-based flags detected. The company's low dilution risk is supported by the absence of recent equity issuances or shelf registration activity in the available data.
Recent events include the continued demand for diagnostic testing, particularly in the context of the ongoing global health environment. The company has not disclosed any major new product launches or strategic partnerships in the latest filings, but the high analyst price targets suggest confidence in its future performance.
- Spruce Biosciences has a strong liquidity position with $81.15 million in cash and equivalents, but it is currently unprofitable with a net loss of $11.63 million.
- The company's price-to-book ratio of 2.39 and debt-to-equity ratio of 0.04 indicate a premium valuation with minimal leverage.
- Analysts have assigned high price targets, ranging from $140 to $283 per share, suggesting optimism about the company's long-term potential.
- The company's profitability metrics, including ROE and ROA, are negative, indicating poor capital efficiency and asset utilization.
- Spruce Biosciences operates in a high-growth but volatile sector, with revenue primarily derived from diagnostic test sales in the U.S.
Bull / Bear case
Generated · model-assistedIn focus — financials by report
Revenue $0.00, −100,0% YoY; Operating income +53,9% YoY.
- ▍Revenue $0.00, −100,0% YoY
- ▍Operating income +53,9% YoY
- ▍Net income +37,8% YoY
- ▍Free cash flow +37,8% YoY
Revenue $0.00, −100,0% YoY; Operating income +12,5% YoY.
- ▍Revenue $0.00, −100,0% YoY
- ▍Operating income +12,5% YoY
- ▍Net income +5,3% YoY
- ▍Free cash flow +5,2% YoY
Revenue $0.00, −100,0% YoY; Operating income +73,2% YoY.
- ▍Revenue $0.00, −100,0% YoY
- ▍Operating income +73,2% YoY
- ▍Net income +77,5% YoY
- ▍Free cash flow +77,5% YoY
Revenue $0.00, −100,0% YoY; Operating income −14,7% YoY.
- ▍Revenue $0.00, −100,0% YoY
- ▍Operating income −14,7% YoY
- ▍Net income −20,8% YoY
- ▍Free cash flow −20,9% YoY
Revenue $697.0k; Operating income -$24.1M.
- ▍Revenue $697.0k
- ▍Operating income -$24.1M
- ▍Net margin -3380.1%
Revenue $602.0k; Operating income -$9.4M.
- ▍Revenue $602.0k
- ▍Operating income -$9.4M
- ▍Net margin -1440.4%
Revenue $1.6M; Operating income -$10.0M.
- ▍Revenue $1.6M
- ▍Operating income -$10.0M
- ▍Net margin -570.2%
Revenue $2.0M; Operating income -$12.6M.
- ▍Revenue $2.0M
- ▍Operating income -$12.6M
- ▍Net margin -580.7%
Revenue $0.00, −100,0% YoY; Operating income +35,0% YoY.
- ▍Revenue $0.00, −100,0% YoY
- ▍Operating income +35,0% YoY
- ▍Net income +26,5% YoY
- ▍Free cash flow +26,5% YoY
Revenue $4.9M, −51,3% YoY; Operating income −8,0% YoY.
- ▍Revenue $4.9M, −51,3% YoY
- ▍Operating income −8,0% YoY
- ▍Net income −10,7% YoY
- ▍Free cash flow −10,7% YoY
- ▍Net margin -1079.9%
Revenue $10.1M; Operating income −10,0% YoY.
- ▍Revenue $10.1M
- ▍Operating income −10,0% YoY
- ▍Net income −3,8% YoY
- ▍Free cash flow −3,8% YoY
- ▍Net margin -475.0%
Operating income −12,4% YoY; Net income −9,2% YoY.
- ▍Operating income −12,4% YoY
- ▍Net income −9,2% YoY
- ▍Free cash flow −9,0% YoY
Valuation TTM
Revenue by segment
Business relationships
Supply chain
Peer comparison
Market position
Stress test
Predictor forecast
| Metric | Our forecast | Guidance | Consensus |
|---|---|---|---|
| EPS | —no estimate | —no estimate | -36,72 |
| Revenue | —no estimate | —no estimate | 0 USD |
| Operating income | —no estimate | —no estimate | -46,9M USD |
Options
Short squeeze
Earnings-call key lines
Consensus distribution
sell-side coverageEstimate revisions
consensus EPS · 26-week trendSell-side observations
Themes
ESG
Risk factors
- No immediate filing-based liquidity or dilution flags were detected.
Benchmarks vs cohort
Corporate actions / M&A
FX exposure
Comparable transactions
Derivatives & instruments
Derivative transactions
- Director, Executive Chairman · Stock Option (Right to Buy) → Common StockAcquired 1 700 @ $52,70grant · 2026-05-21
- Director · Stock Option (Right to Buy) → Common StockAcquired 1 700 @ $52,70grant · 2026-05-21
- Director · Stock Option (Right to Buy) → Common StockAcquired 1 700 @ $52,70grant · 2026-05-21
- Director · Stock Option (Right to Buy) → Common StockAcquired 1 700 @ $52,70grant · 2026-05-21
- Director · Stock Option (Right to Buy) → Common StockAcquired 1 700 @ $52,70grant · 2026-05-21
- Chief Commercial Officer · Restricted Stock Units → Common StockAcquired 11 000grant · 2026-03-09
- Director, CHIEF EXECUTIVE OFFICER · Restricted Stock Units → Common StockDisposed 1 196exercise · 2025-12-15
- PRESIDENT AND CFO · Restricted Stock Units → Common StockDisposed 496exercise · 2025-12-15
- PRESIDENT AND CFO · Restricted Stock Units → Common StockDisposed 513exercise · 2025-12-15
- Director, CHIEF EXECUTIVE OFFICER · Restricted Stock Units → Common StockDisposed 1 480exercise · 2025-12-15
- PRESIDENT AND CFO · Restricted Stock Units → Common StockAcquired 7 600grant · 2025-12-11
- PRESIDENT AND CFO · Restricted Stock Units → Common StockDisposed 1 900exercise · 2025-12-11
- Director · Stock Option (Right to Buy) → Common StockAcquired 458 @ $104,13grant · 2025-12-11
- Director, Interim Chief Medical Officer · Restricted Stock Units → Common StockAcquired 5 000grant · 2025-12-11
- Director, Interim Chief Medical Officer · Restricted Stock Units → Common StockDisposed 1 250exercise · 2025-12-11
- Director, CHIEF EXECUTIVE OFFICER · Employee Stock Option (right to buy) → Common StockAcquired 1 666 @ $104,13grant · 2025-12-11
- Director · Stock Option (Right to Buy) → Common StockDisposed 458 @ $564,00disposition · 2025-12-11
- Director · Stock Option (Right to Buy) → Common StockAcquired 3 400 @ $88,41grant · 2025-12-11
- Director, CHIEF EXECUTIVE OFFICER · Employee Stock Option (right to buy) → Common StockDisposed 1 666 @ $344,25disposition · 2025-12-11
- Director, CHIEF EXECUTIVE OFFICER · Restricted Stock Units → Common StockDisposed 4 950exercise · 2025-12-11
- Director, Interim Chief Medical Officer · Stock Option (Right to Buy) → Common StockDisposed 400 @ $169,50disposition · 2025-12-11
- Director, Interim Chief Medical Officer · Stock Option (Right to Buy) → Common StockAcquired 400 @ $104,13grant · 2025-12-11
- Director, CHIEF EXECUTIVE OFFICER · Restricted Stock Units → Common StockAcquired 19 800grant · 2025-12-11
- Director, Interim Chief Medical Officer · Stock Option (Right to Buy) → Common StockAcquired 266 @ $104,13grant · 2025-12-11
- Director, Interim Chief Medical Officer · Stock Option (Right to Buy) → Common StockDisposed 266 @ $791,25disposition · 2025-12-11
Actions
Ask Handelsavisen
- Market data
- Market data cache
- Issuer disclosures
- Public news
- Earnings transcripts
- Consensus estimates
- ESG data
- Return On Equitynet_income / total_equity
- Price To Bookmarket_price / (adjusted_book_value / shares_outstanding_diluted)
- Dilution Ratio(shares_outstanding_diluted - shares_outstanding_basic) / shares_outstanding_basic
- Market Priceinput from market-data provider (delayed close or quote-shim mid)
- Market Capmarket_price * shares_outstanding_diluted
- Ev To Revenueenterprise_value / revenue
- Spruce Biosciences, Inc Market data — financials · 2026-05-29
- Spruce Biosciences, Inc Market data — analyst estimates · 2026-05-29
- Spruce Biosciences, Inc Market data — ESG · 2026-05-29
Ownership & reference
Top holders
- Investment Managers · as of 2026-03-310,00 %$3M
- Investment Managers · as of 2026-03-310,00 %$1M
- Investment Managers · as of 2026-03-310,00 %$0M
- Investment Managers · as of 2026-03-310,00 %$0M
- Investment Managers · as of 2025-12-310,00 %$2M
- Investment Managers · as of 2026-03-310,00 %$0M
- Institutional Investor · as of 2026-03-310,00 %$0M
- Investment Managers · as of 2026-03-310,00 %$0M
- Investment Managers · as of 2024-06-300,00 %$0M
Leadership
- Mike G. GreyExecutive Chairman of the Board
Insider activity
- Director, CHIEF EXECUTIVE OFFICER · Common StockOther 4 690 @ $4,53$21K · 2025-12-31
- Director, CHIEF EXECUTIVE OFFICER · Common StockOther 752 @ $80,67$61K · 2025-12-15
- PRESIDENT AND CFO · Common StockOther 496 · 2025-12-15
- PRESIDENT AND CFO · Common StockOther 178 @ $80,67$14K · 2025-12-15
- PRESIDENT AND CFO · Common StockOther 513 · 2025-12-15
- PRESIDENT AND CFO · Common StockOther 184 @ $80,67$15K · 2025-12-15
- Director, CHIEF EXECUTIVE OFFICER · Common StockOther 1 480 · 2025-12-15
- Director, CHIEF EXECUTIVE OFFICER · Common StockOther 1 196 · 2025-12-15
- Director, CHIEF EXECUTIVE OFFICER · Common StockOther 608 @ $80,67$49K · 2025-12-15
- Director, Interim Chief Medical Officer · Common StockOther 1 250 · 2025-12-11
- PRESIDENT AND CFO · Common StockOther 1 900 · 2025-12-11
- Director, CHIEF EXECUTIVE OFFICER · Common StockOther 4 950 · 2025-12-11
- Director, CHIEF EXECUTIVE OFFICER · Common StockOther 2 194 @ $88,41$194K · 2025-12-11
- PRESIDENT AND CFO · Common StockOther 680 @ $88,41$60K · 2025-12-11
- PRESIDENT AND CFO · Common StockOther 514 · 2025-12-10
- PRESIDENT AND CFO · Common StockOther 184 @ $85,67$16K · 2025-12-10
- Director, CHIEF EXECUTIVE OFFICER · Common StockOther 1 196 · 2025-12-10
- Director, CHIEF EXECUTIVE OFFICER · Common StockOther 428 @ $85,67$37K · 2025-12-10
- PRESIDENT AND CFO · Common StockOther 2 053 · 2025-10-20
- PRESIDENT AND CFO · Common StockOther 661 @ $148,16$98K · 2025-10-20
- Director, CHIEF EXECUTIVE OFFICER · Common StockOther 4 784 · 2025-10-20
- Director, CHIEF EXECUTIVE OFFICER · Common StockOther 1 539 @ $148,16$228K · 2025-10-20
- 10% owner · Common Stock, $0.001 par value per shareSold 232 @ $19,33$4K · 2025-10-06
- 10% owner · Common Stock, $0.001 par value per shareBought 256 @ $17,91$5K · 2025-10-06
- 10% owner · Common Stock, $0.001 par value per shareSold 25 @ $17,46$436 · 2025-10-06
Short positioning
Geographic breakdown
Intel & risk
Evidence & claims
From filings & derived data- EPS (diluted) (YoY) (2025-12-31 vs 2024-12-31): 47.3%Derived (calculated)
- EPS (basic) (YoY) (2025-12-31 vs 2024-12-31): 47.3%Derived (calculated)
- Total liabilities (YoY) (2025-12-31 vs 2024-12-31): -35.9%Derived (calculated)
- Total assets (YoY) (2025-12-31 vs 2024-12-31): 17.3%Derived (calculated)
- Shareholders' equity (YoY) (2025-12-31 vs 2024-12-31): 47.5%Derived (calculated)
- R&D expense (YoY) (2025-12-31 vs 2024-12-31): -57.9%Derived (calculated)
- Return on equity (FY 2025-12-31): -91.7%Derived (calculated)
- Operating income (YoY) (2025-12-31 vs 2024-12-31): 35.0%Derived (calculated)
- Operating cash flow (YoY) (2025-12-31 vs 2024-12-31): 40.4%Derived (calculated)
- Long-term debt (YoY) (2025-12-31 vs 2024-12-31): -100.0%Derived (calculated)
- Net income (YoY) (2025-12-31 vs 2024-12-31): 26.5%Derived (calculated)
- Cash & equivalents (YoY) (2025-12-31 vs 2024-12-31): 26.2%Derived (calculated)
- Debt-to-equity (FY 2025-12-31): 0.25xDerived (calculated)
- Current ratio (FY 2025-12-31): 5.17xDerived (calculated)
- Return on assets (FY 2025-12-31): -73.5%Derived (calculated)
- Revenue (YoY) (2025-12-31 vs 2024-12-31): -100.0%Derived (calculated)
- Total liabilities (annual): USD 10.51MSEC XBRL filing
- Total assets (annual): USD 53.02MSEC XBRL filing
- Interest expense (annual): USD 90KSEC XBRL filing
- R&D expense (annual): USD 19.52MSEC XBRL filing
- EPS (diluted) (annual): USD-PER-SHARES -51SEC XBRL filing
- Long-term debt (annual): USD 0SEC XBRL filing
- Operating income (annual): USD -36.51MSEC XBRL filing
- Revenue (annual): USD 0SEC XBRL filing