The Lima Stock Exchange (BVL) opened in negative territory on Wednesday, mirroring the volatility that has gripped Wall Street.
The decline in Peru's primary market comes as US investors continue to secure profits following recent gains, creating headwinds for emerging-market equities across the region.
The sell-off in Lima is part of a wider regional downturn.
Mexico's benchmark IPC index extended its losing streak to six consecutive sessions, closing down 0.85% at 66,278 points.
The decline in Mexico was driven primarily by weakness in the mining sector, which weighed heavily on the index.
This synchronized weakness highlights the continued sensitivity of Latin American markets to US equity trends.