The DAX is set to open roughly 0.5% lower at 24,997 points on Tuesday, as European investors react to a sharp escalation in geopolitical tensions between the United States and Iran.
The German benchmark, which showed resilience earlier in the week, faces renewed selling pressure as the risk premium associated with Middle East instability widens across global markets.
The downturn in Frankfurt mirrors broader weakness seen in Asia and the US.
Indian equity benchmarks opened sharply lower on Tuesday, extending a multi-day selloff driven by fears of supply chain disruptions and energy price spikes.
Meanwhile, US markets are poised to open lower on Monday, digesting reports that both nations engaged in military attacks over the weekend.
The conflict has reignited concerns about potential disruptions to global shipping routes and energy supplies.