US equity markets opened lower on Wednesday, with major indexes sliding as investors reacted to a sharp escalation in Middle East tensions.

The sell-off was triggered by reports that the United States and Iran exchanged fire, reigniting fears of a broader regional conflict that could disrupt global energy supplies.

Brent crude prices surged in response to the heightened geopolitical risk, adding pressure to an already sensitive inflation outlook.

The rise in energy costs threatens to complicate the Federal Reserve’s path, as policymakers balance cooling labor market data against persistent price pressures.

The decline in Wall Street extended to Asia-Pacific markets on Thursday, where regional indexes also opened lower following the overnight drop in the US.

Investors are increasingly focused on the potential for supply chain disruptions and higher household energy costs, which could dampen consumer spending in the coming quarters.

With the FOMC meeting approaching, market participants are closely watching for any signals on how the central bank will respond to the renewed inflationary pressures.

The conflict has raised concerns about energy supply and inflation, weighing on risk sentiment across global markets.